Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1372979..1373462 Replicon chromosome
Accession NC_022516
Organism Streptococcus suis YB51

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag YB51_RS06735 Protein ID WP_009910443.1
Coordinates 1372979..1373239 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag YB51_RS06740 Protein ID WP_012775256.1
Coordinates 1373241..1373462 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YB51_RS06710 1368364..1369593 - 1230 WP_009910437.1 tetratricopeptide repeat protein -
YB51_RS06715 1369583..1370749 - 1167 WP_002935690.1 AI-2E family transporter -
YB51_RS06720 1370885..1371889 + 1005 WP_009910438.1 lactonase family protein -
YB51_RS06725 1371953..1372138 + 186 WP_002935693.1 hypothetical protein -
YB51_RS06730 1372171..1372812 - 642 WP_002935700.1 HAD family hydrolase -
YB51_RS06735 1372979..1373239 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YB51_RS06740 1373241..1373462 - 222 WP_012775256.1 hypothetical protein Antitoxin
YB51_RS06745 1373772..1375079 - 1308 WP_002935704.1 phosphopyruvate hydratase -
YB51_RS06750 1375229..1375681 + 453 WP_013730449.1 DUF1694 domain-containing protein -
YB51_RS06755 1375691..1375918 - 228 WP_002935708.1 hypothetical protein -
YB51_RS06760 1375909..1377036 - 1128 WP_002935718.1 glycerate kinase -
YB51_RS06765 1377144..1377794 + 651 WP_002935722.1 HAD family hydrolase -
YB51_RS06770 1377825..1378460 - 636 WP_002935723.1 phosphoserine phosphatase SerB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T30138 WP_009910443.1 NC_022516:c1373239-1372979 [Streptococcus suis YB51]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T30138 NC_022516:c1373239-1372979 [Streptococcus suis YB51]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT30138 WP_012775256.1 NC_022516:c1373462-1373241 [Streptococcus suis YB51]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT30138 NC_022516:c1373462-1373241 [Streptococcus suis YB51]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References