Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1026389..1026875 Replicon chromosome
Accession NC_022516
Organism Streptococcus suis YB51

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag YB51_RS05050 Protein ID WP_002935012.1
Coordinates 1026389..1026646 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag YB51_RS05055 Protein ID WP_002935014.1
Coordinates 1026636..1026875 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YB51_RS05030 1022023..1023093 + 1071 WP_002935006.1 tyrosine recombinase XerS -
YB51_RS05035 1023163..1024671 - 1509 WP_013730362.1 phosphoglucomutase -
YB51_RS05040 1024747..1025688 - 942 WP_002935009.1 sensor histidine kinase -
YB51_RS05045 1025685..1026350 - 666 WP_009909826.1 response regulator transcription factor -
YB51_RS05050 1026389..1026646 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YB51_RS05055 1026636..1026875 - 240 WP_002935014.1 hypothetical protein Antitoxin
YB51_RS05060 1026967..1028937 - 1971 WP_013730363.1 FtsX-like permease family protein -
YB51_RS05065 1028938..1029690 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
YB51_RS05070 1029707..1030090 - 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
YB51_RS05075 1030103..1030243 - 141 WP_002935023.1 hypothetical protein -
YB51_RS05080 1030342..1031076 - 735 WP_013730364.1 beta-carotene 15,15'-monooxygenase -
YB51_RS10675 1031089..1031226 - 138 WP_002935027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T30137 WP_002935012.1 NC_022516:c1026646-1026389 [Streptococcus suis YB51]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T30137 NC_022516:c1026646-1026389 [Streptococcus suis YB51]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT30137 WP_002935014.1 NC_022516:c1026875-1026636 [Streptococcus suis YB51]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT30137 NC_022516:c1026875-1026636 [Streptococcus suis YB51]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References