Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 786829..787315 Replicon chromosome
Accession NC_022516
Organism Streptococcus suis YB51

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag YB51_RS03960 Protein ID WP_011922754.1
Coordinates 787046..787315 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag YB51_RS03955 Protein ID WP_002938604.1
Coordinates 786829..787056 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YB51_RS03930 782160..782723 - 564 WP_041179349.1 NAD(P)H-dependent oxidoreductase -
YB51_RS03935 782769..783218 - 450 WP_002938613.1 MarR family transcriptional regulator -
YB51_RS03940 783521..784018 + 498 WP_002938611.1 DUF5590 domain-containing protein -
YB51_RS03945 784015..785196 + 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
YB51_RS03950 785211..786557 + 1347 WP_013730302.1 asparagine--tRNA ligase -
YB51_RS03955 786829..787056 + 228 WP_002938604.1 hypothetical protein Antitoxin
YB51_RS03960 787046..787315 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YB51_RS03965 787721..789040 + 1320 WP_002937278.1 MATE family efflux transporter -
YB51_RS03970 789224..789601 + 378 WP_013730303.1 RidA family protein -
YB51_RS03975 789623..790510 + 888 WP_002937261.1 RNase adapter RapZ -
YB51_RS03980 790507..791481 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T30136 WP_011922754.1 NC_022516:787046-787315 [Streptococcus suis YB51]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T30136 NC_022516:787046-787315 [Streptococcus suis YB51]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT30136 WP_002938604.1 NC_022516:786829-787056 [Streptococcus suis YB51]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT30136 NC_022516:786829-787056 [Streptococcus suis YB51]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References