Detailed information of TA system TA030127

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 852025..852557
• Replicon: chromosome
• Accession: NC_022443
• Organism: Staphylococcus aureus subsp. aureus SA40

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: SA40_RS04105
• Protein ID: WP_001103942.1
• Coordinates: 852237..852557 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: SA40_RS04100
• Protein ID: WP_001058486.1
• Coordinates: 852025..852234 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA40_RS04055	847044..848264	-	1221	WP_000266157.1	site-specific integrase	-
SA40_RS04060	848353..849081	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
SA40_RS04065	849105..849833	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
SA40_RS04070	849903..850334	-	432	WP_001228759.1	hypothetical protein	-
SA40_RS04075	850351..850809	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
SA40_RS04080	850821..851153	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
SA40_RS04085	851346..851609	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
SA40_RS04090	851602..851874	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
SA40_RS04095	851886..852032	+	147	WP_000784875.1	hypothetical protein	-
SA40_RS04100	852025..852234	+	210	WP_001058486.1	hypothetical protein	Antitoxin
SA40_RS04105	852237..852557	+	321	WP_001103942.1	DUF1474 family protein	Toxin
SA40_RS04110	852621..853490	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
SA40_RS04115	853507..854976	+	1470	WP_000390454.1	virulence-associated E family protein	-
SA40_RS04120	855262..855624	+	363	WP_001039168.1	hypothetical protein	-
SA40_RS04125	855626..855910	+	285	WP_000998181.1	hypothetical protein	-
SA40_RS04130	855907..856548	+	642	WP_021758233.1	pathogenicity island protein	-
SA40_RS04135	857065..857406	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	841608..862357	20749

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T30127 WP_001103942.1 NC_022443:852237-852557 [Staphylococcus aureus subsp. aureus SA40]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T30127 NC_022443:852237-852557 [Staphylococcus aureus subsp. aureus SA40]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT30127 WP_001058486.1 NC_022443:852025-852234 [Staphylococcus aureus subsp. aureus SA40]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT30127 NC_022443:852025-852234 [Staphylococcus aureus subsp. aureus SA40]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4