Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 834329..834806 Replicon chromosome
Accession NC_022443
Organism Staphylococcus aureus subsp. aureus SA40

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SA40_RS03950 Protein ID WP_000052076.1
Coordinates 834329..834517 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SA40_RS03955 Protein ID WP_001059690.1
Coordinates 834546..834806 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA40_RS03920 830367..830837 + 471 WP_000824462.1 hypothetical protein -
SA40_RS03925 831178..831864 + 687 WP_001823812.1 thermonuclease family protein -
SA40_RS03930 832221..832421 + 201 WP_001059082.1 cold-shock protein -
SA40_RS03935 832920..833138 - 219 WP_000005888.1 hypothetical protein -
SA40_RS03940 833200..833484 - 285 WP_001004397.1 hypothetical protein -
SA40_RS03945 833572..834141 - 570 WP_001106657.1 hypothetical protein -
SA40_RS03950 834329..834517 - 189 WP_000052076.1 hypothetical protein Toxin
SA40_RS03955 834546..834806 - 261 WP_001059690.1 hypothetical protein Antitoxin
SA40_RS03960 835147..835350 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SA40_RS03965 835347..835583 - 237 WP_000368687.1 hypothetical protein -
SA40_RS03970 835808..836389 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
SA40_RS03975 836462..837079 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
SA40_RS03980 837235..837729 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SA40_RS03985 838128..838550 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SA40_RS03990 838698..839414 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T30126 WP_000052076.1 NC_022443:c834517-834329 [Staphylococcus aureus subsp. aureus SA40]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T30126 NC_022443:c834517-834329 [Staphylococcus aureus subsp. aureus SA40]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT30126 WP_001059690.1 NC_022443:c834806-834546 [Staphylococcus aureus subsp. aureus SA40]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT30126 NC_022443:c834806-834546 [Staphylococcus aureus subsp. aureus SA40]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References