Detailed information of TA system TA030117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 870414..870946
• Replicon: chromosome
• Accession: NC_022442
• Organism: Staphylococcus aureus subsp. aureus SA957

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: SA957_RS04180
• Protein ID: WP_001103942.1
• Coordinates: 870626..870946 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: SA957_RS04175
• Protein ID: WP_001058486.1
• Coordinates: 870414..870623 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA957_RS04130	865434..866654	-	1221	WP_000266157.1	site-specific integrase	-
SA957_RS04135	866742..867470	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
SA957_RS04140	867494..868222	-	729	WP_001033318.1	staphylococcal enterotoxin type Q	-
SA957_RS04145	868292..868723	-	432	WP_001228759.1	hypothetical protein	-
SA957_RS04150	868740..869198	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
SA957_RS04155	869210..869542	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
SA957_RS04160	869735..869998	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
SA957_RS04165	869991..870263	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
SA957_RS04170	870275..870421	+	147	WP_000784875.1	hypothetical protein	-
SA957_RS04175	870414..870623	+	210	WP_001058486.1	hypothetical protein	Antitoxin
SA957_RS04180	870626..870946	+	321	WP_001103942.1	DUF1474 family protein	Toxin
SA957_RS04185	871010..871879	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
SA957_RS04190	871896..873365	+	1470	WP_000390454.1	virulence-associated E family protein	-
SA957_RS04195	873651..874013	+	363	WP_001039168.1	hypothetical protein	-
SA957_RS04200	874015..874299	+	285	WP_000998181.1	hypothetical protein	-
SA957_RS04205	874296..874937	+	642	WP_001019764.1	hypothetical protein	-
SA957_RS04210	875454..875795	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	847399..880746	33347

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T30117 WP_001103942.1 NC_022442:870626-870946 [Staphylococcus aureus subsp. aureus SA957]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T30117 NC_022442:870626-870946 [Staphylococcus aureus subsp. aureus SA957]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT30117 WP_001058486.1 NC_022442:870414-870623 [Staphylococcus aureus subsp. aureus SA957]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT30117 NC_022442:870414-870623 [Staphylococcus aureus subsp. aureus SA957]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4