Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 852719..853196 Replicon chromosome
Accession NC_022442
Organism Staphylococcus aureus subsp. aureus SA957

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SA957_RS04025 Protein ID WP_000052076.1
Coordinates 852719..852907 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SA957_RS04030 Protein ID WP_001059690.1
Coordinates 852936..853196 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA957_RS03995 848757..849227 + 471 WP_000824462.1 hypothetical protein -
SA957_RS04000 849568..850254 + 687 WP_001823812.1 thermonuclease family protein -
SA957_RS04005 850611..850811 + 201 WP_001059082.1 cold-shock protein -
SA957_RS04010 851310..851528 - 219 WP_000005888.1 hypothetical protein -
SA957_RS04015 851590..851874 - 285 WP_001004397.1 hypothetical protein -
SA957_RS04020 851962..852531 - 570 WP_001106657.1 hypothetical protein -
SA957_RS04025 852719..852907 - 189 WP_000052076.1 hypothetical protein Toxin
SA957_RS04030 852936..853196 - 261 WP_001059690.1 hypothetical protein Antitoxin
SA957_RS04035 853537..853740 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SA957_RS04040 853737..853973 - 237 WP_000368687.1 hypothetical protein -
SA957_RS04045 854198..854779 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
SA957_RS04050 854852..855469 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
SA957_RS04055 855625..856119 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SA957_RS04060 856518..856940 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SA957_RS04065 857088..857804 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 847399..880746 33347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T30116 WP_000052076.1 NC_022442:c852907-852719 [Staphylococcus aureus subsp. aureus SA957]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T30116 NC_022442:c852907-852719 [Staphylococcus aureus subsp. aureus SA957]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT30116 WP_001059690.1 NC_022442:c853196-852936 [Staphylococcus aureus subsp. aureus SA957]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT30116 NC_022442:c853196-852936 [Staphylococcus aureus subsp. aureus SA957]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References