Detailed information of TA system TA030113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1292770..1293314
• Replicon: chromosome
• Accession: NC_022438
• Organism: Leifsonia xyli subsp. cynodontis DSM 46306

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: O159_RS06090
• Protein ID: WP_043994089.1
• Coordinates: 1292770..1293006 (-)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3P547
• Locus tag: O159_RS06095
• Protein ID: WP_021754877.1
• Coordinates: 1293045..1293314 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
O159_RS06070	1288424..1288846	-	423	WP_021754870.1	Hsp20/alpha crystallin family protein	-
O159_RS13940	1289234..1289416	+	183	WP_021754871.1	transposase	-
O159_RS06075	1289586..1290074	-	489	WP_021754872.1	PIN domain-containing protein	-
O159_RS06080	1290067..1290336	-	270	WP_021754873.1	hypothetical protein	-
O159_RS06085	1290724..1292313	+	1590	WP_081689832.1	amidase domain-containing protein	-
O159_RS06090	1292770..1293006	-	237	WP_043994089.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
O159_RS06095	1293045..1293314	-	270	WP_021754877.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
O159_RS13225	1293457..1294032	-	576	WP_021754878.1	RES domain-containing protein	-
O159_RS06105	1294035..1294388	-	354	WP_021754879.1	MbcA/ParS/Xre antitoxin family protein	-
O159_RS06110	1294523..1295206	+	684	WP_081689834.1	N-6 DNA methylase	-
O159_RS06115	1295203..1295775	+	573	WP_021754881.1	hypothetical protein	-
O159_RS06120	1295923..1296351	+	429	WP_021754882.1	restriction endonuclease subunit S	-
O159_RS13950	1296447..1297306	-	860	Protein_1230	IS5 family transposase	-
O159_RS06130	1297290..1298018	-	729	WP_021754883.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1290724..1303300	12576

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-75)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 8930.49 Da
• Isoelectric Point: 10.4196

>T30113 WP_043994089.1 NC_022438:c1293006-1292770 [Leifsonia xyli subsp. cynodontis DSM 46306]
MRALSRLPEKMADAVLRFLDGPLTENPMRVTKPLGAELDSMRSGYVGIAYRVLVRIDEDKRVVQVMRIAHRADAYRPF

Nucleotide

• Length: 237 bp

>T30113 NC_022438:c1293006-1292770 [Leifsonia xyli subsp. cynodontis DSM 46306]
ATGCGCGCGCTGAGCCGACTGCCGGAGAAGATGGCGGATGCTGTTTTGCGGTTCTTGGATGGTCCGCTGACCGAGAATCC
GATGCGGGTGACCAAGCCTCTGGGTGCTGAGCTGGATAGCATGCGGTCTGGTTACGTCGGGATCGCCTACCGTGTGCTGG
TTCGCATCGATGAGGACAAGCGTGTGGTGCAGGTGATGCGCATCGCGCATCGAGCGGATGCATACCGACCCTTCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9582.79 Da
• Isoelectric Point: 4.1947

>AT30113 WP_021754877.1 NC_022438:c1293314-1293045 [Leifsonia xyli subsp. cynodontis DSM 46306]
MQTMSVSEAKDKLSNLVEGVEATHDAVVITRHGKPAAVLISPEDLDSLQEMLAWLSDPAHAAEMAEAEEDVAAGRMLSLD
EVRAQLANR

Nucleotide

• Length: 270 bp

>AT30113 NC_022438:c1293314-1293045 [Leifsonia xyli subsp. cynodontis DSM 46306]
ATGCAGACAATGTCGGTGAGTGAAGCGAAGGACAAGCTCTCGAATCTGGTCGAGGGTGTTGAGGCCACGCATGATGCGGT
GGTGATTACGCGGCACGGGAAGCCGGCCGCGGTGCTGATTTCACCTGAGGATCTCGACTCGCTGCAGGAGATGTTGGCTT
GGTTGTCGGATCCAGCTCATGCTGCGGAGATGGCCGAGGCGGAGGAGGATGTCGCTGCGGGTCGGATGTTGTCGTTGGAT
GAGGTTCGCGCGCAGCTGGCGAATCGGTGA

Structures

Antitoxin

• AlphaFold DB: U3P547