30101

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2670506..2671131 Replicon chromosome
Accession NC_022364
Organism Escherichia coli LY180

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag LY180_RS13200 Protein ID WP_000911329.1
Coordinates 2670506..2670904 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag LY180_RS13205 Protein ID WP_000450524.1
Coordinates 2670904..2671131 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY180_RS13180 2666413..2666613 + 201 WP_000383836.1 YpfN family protein -
LY180_RS13185 2666694..2667392 - 699 WP_000679823.1 esterase -
LY180_RS13190 2667466..2669481 - 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
LY180_RS13195 2669496..2670359 - 864 WP_001267505.1 neutral zinc metallopeptidase -
LY180_RS13200 2670506..2670904 - 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
LY180_RS13205 2670904..2671131 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
LY180_RS13210 2671286..2671999 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
LY180_RS13220 2672212..2673246 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
LY180_RS13225 2673263..2674141 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
LY180_RS13230 2674287..2674859 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
LY180_RS13235 2674859..2675329 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T30101 WP_000911329.1 NC_022364:c2670904-2670506 [Escherichia coli LY180]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T30101 NC_022364:c2670904-2670506 [Escherichia coli LY180]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT30101 WP_000450524.1 NC_022364:c2671131-2670904 [Escherichia coli LY180]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT30101 NC_022364:c2671131-2670904 [Escherichia coli LY180]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References