Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 551919..552537 Replicon chromosome
Accession NC_022364
Organism Escherichia coli LY180

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LY180_RS02700 Protein ID WP_001291435.1
Coordinates 551919..552137 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LY180_RS02705 Protein ID WP_000344800.1
Coordinates 552163..552537 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY180_RS02670 547208..547780 + 573 WP_000779826.1 lipoprotein -
LY180_RS02675 547811..548122 - 312 WP_000409911.1 MGMT family protein -
LY180_RS02680 548501..548854 + 354 WP_000878140.1 DUF1428 domain-containing protein -
LY180_RS02685 548896..550446 - 1551 Protein_519 cyclic-guanylate-specific phosphodiesterase PdeB -
LY180_RS02690 550610..551080 - 471 WP_000136192.1 YlaC family protein -
LY180_RS02695 551196..551747 - 552 WP_000102564.1 maltose O-acetyltransferase -
LY180_RS02700 551919..552137 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
LY180_RS02705 552163..552537 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LY180_RS02710 553083..556232 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
LY180_RS02715 556255..557448 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T30084 WP_001291435.1 NC_022364:c552137-551919 [Escherichia coli LY180]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T30084 NC_022364:c552137-551919 [Escherichia coli LY180]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT30084 WP_000344800.1 NC_022364:c552537-552163 [Escherichia coli LY180]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT30084 NC_022364:c552537-552163 [Escherichia coli LY180]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References