Detailed information of TA system TA030080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2181322..2182428
• Replicon: chromosome
• Accession: NC_022357
• Organism: Sulfuricella denitrificans skB26

Toxin (Protein)

• Gene name: -
• Uniprot ID: S6AAJ0
• Locus tag: SCD_RS10575
• Protein ID: WP_009205142.1
• Coordinates: 2181682..2182428 (+)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: S6AMC8
• Locus tag: SCD_RS10570
• Protein ID: WP_009205141.1
• Coordinates: 2181322..2181681 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SCD_RS10555	2177632..2178558	-	927	WP_023506949.1	bifunctional riboflavin kinase/FAD synthetase	-
SCD_RS10560	2178741..2180285	-	1545	WP_009205139.1	murein biosynthesis integral membrane protein MurJ	-
SCD_RS10565	2180461..2181045	+	585	WP_009205140.1	superoxide dismutase	-
SCD_RS10570	2181322..2181681	+	360	WP_009205141.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
SCD_RS10575	2181682..2182428	+	747	WP_009205142.1	RES family NAD+ phosphorylase	Toxin
SCD_RS10580	2182522..2184375	+	1854	WP_009205143.1	thioredoxin domain-containing protein	-
SCD_RS10585	2184587..2185537	+	951	WP_009205144.1	tRNA-dihydrouridine synthase family protein	-
SCD_RS10590	2185534..2186415	-	882	WP_009205145.1	protease HtpX	-
SCD_RS10595	2186419..2186973	-	555	WP_148290849.1	YqhA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-205)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (9-64)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 27642.39 Da
• Isoelectric Point: 7.5447

>T30080 WP_009205142.1 NC_022357:2181682-2182428 [Sulfuricella denitrificans skB26]
VVNWNACLATTKPVRLSGSLLRLVESQEQVATHQLVSSLSRQAALEDMLEATKPPLRKHSEGLHYLLATPFRYPPLKHGS
RFGSRNEPSLFYGSQGTRTVLMEAAYYRFVFWFGMTTPPFGKLDTQHTLFEAAYQTDRGFKLQAQPFTAYHAELTHPADY
QTSQALGAILRADGIQAFEFASARDPEGGINVALFTPEAFPGKNPISQESWFCELTGERVRFHAVRGTGIHEFPIEIFLV
GGKLPQPA

Nucleotide

• Length: 747 bp

>T30080 NC_022357:2181682-2182428 [Sulfuricella denitrificans skB26]
GTGGTCAACTGGAATGCCTGCCTGGCAACTACCAAGCCGGTCAGGCTCTCAGGCAGCTTGCTTCGTCTCGTGGAAAGTCA
GGAGCAAGTGGCAACACACCAGCTTGTCAGCTCACTTAGCCGGCAGGCCGCACTCGAAGACATGCTGGAAGCAACCAAGC
CTCCTTTGCGCAAACACTCCGAGGGACTTCATTATCTGCTGGCCACGCCGTTCCGCTATCCGCCCCTGAAGCATGGTTCC
CGCTTTGGCTCACGCAACGAACCCAGCCTGTTTTACGGTTCCCAGGGAACCAGGACCGTCCTTATGGAGGCAGCCTACTA
CCGCTTCGTATTCTGGTTTGGCATGACGACGCCTCCATTCGGCAAGTTAGACACCCAACACACTCTATTCGAGGCGGCCT
ATCAGACTGACAGGGGCTTCAAGCTGCAGGCGCAACCGTTCACCGCTTACCATGCCGAACTCACCCATCCCGCTGATTAC
CAGACTAGCCAGGCACTCGGGGCTATCCTGCGAGCAGATGGCATCCAGGCTTTTGAGTTTGCGTCTGCCCGAGATCCTGA
AGGGGGTATCAATGTTGCGCTGTTCACGCCCGAAGCCTTCCCTGGAAAGAACCCTATTTCACAAGAATCCTGGTTCTGTG
AATTAACCGGAGAGCGAGTCAGATTTCATGCTGTCCGCGGCACAGGAATCCATGAATTCCCTATTGAGATTTTCCTGGTA
GGCGGCAAACTTCCGCAGCCCGCTTAG

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 12904.92 Da
• Isoelectric Point: 7.8506

>AT30080 WP_009205141.1 NC_022357:2181322-2181681 [Sulfuricella denitrificans skB26]
MNLAAIQDIDKASVLAEALINAGKNLGMNQSCLGDIIGKDRSAISRGRIEPGSKAGELALLFIRCYRALYVLVGGNYQQM
QHWMQTENTHTGGIPAEQAKTVQGLVTVLEYLDAMRGKL

Nucleotide

• Length: 360 bp

>AT30080 NC_022357:2181322-2181681 [Sulfuricella denitrificans skB26]
ATGAACCTCGCTGCCATTCAGGACATCGACAAAGCCAGCGTCCTCGCAGAAGCACTCATCAACGCCGGGAAGAATCTGGG
TATGAACCAATCCTGTTTGGGCGACATCATCGGCAAGGACCGCTCTGCCATCAGCCGTGGCAGGATTGAACCGGGCAGTA
AGGCCGGTGAATTGGCGCTACTTTTTATCCGCTGCTATCGCGCCCTTTACGTCCTGGTGGGGGGGAATTACCAGCAGATG
CAGCATTGGATGCAGACTGAAAACACCCATACAGGCGGCATACCGGCTGAGCAAGCCAAAACGGTACAAGGTCTGGTCAC
GGTGCTTGAATACCTGGATGCCATGCGAGGAAAGCTTTAA

Structures

Toxin

• AlphaFold DB: S6AAJ0

Antitoxin

• AlphaFold DB: S6AMC8