Detailed information of TA system TA030079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 1438671..1439241
• Replicon: chromosome
• Accession: NC_022357
• Organism: Sulfuricella denitrificans skB26

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: S6AGU9
• Locus tag: SCD_RS07070
• Protein ID: WP_009205794.1
• Coordinates: 1438906..1439241 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S6AA51
• Locus tag: SCD_RS07065
• Protein ID: WP_009205795.1
• Coordinates: 1438671..1438922 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SCD_RS07040	1433812..1434978	+	1167	WP_009205800.1	efflux RND transporter periplasmic adaptor subunit	-
SCD_RS07045	1434975..1436171	+	1197	WP_009205799.1	ABC transporter permease	-
SCD_RS07050	1436171..1436896	+	726	WP_009205798.1	ABC transporter ATP-binding protein	-
SCD_RS07055	1436994..1437515	+	522	WP_009205797.1	hypothetical protein	-
SCD_RS07060	1437519..1438502	+	984	WP_009205796.1	MBL fold metallo-hydrolase	-
SCD_RS07065	1438671..1438922	+	252	WP_009205795.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SCD_RS07070	1438906..1439241	+	336	WP_009205794.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SCD_RS07075	1439514..1439789	+	276	WP_009205793.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
SCD_RS07080	1439776..1440201	+	426	WP_009205792.1	putative toxin-antitoxin system toxin component, PIN family	-
SCD_RS07085	1440326..1443430	+	3105	WP_009205791.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (16-94)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12698.87 Da
• Isoelectric Point: 9.8723

>T30079 WP_009205794.1 NC_022357:1438906-1439241 [Sulfuricella denitrificans skB26]
MLTISEAVQDTPKYRLKFLPEALEEWNALDGSIKEVLRKALKKRLEQPRTPGAQLHADLRDCYKIKLRKQGYRLVYSVED
DVLVVLVLAIDKREGMAAYRSAVERLLAGKS

Nucleotide

• Length: 336 bp

>T30079 NC_022357:1438906-1439241 [Sulfuricella denitrificans skB26]
ATGTTGACAATATCTGAAGCCGTTCAAGACACGCCGAAATACCGGCTCAAATTCCTGCCGGAAGCACTGGAGGAATGGAA
TGCCCTCGATGGCAGCATCAAAGAGGTGCTGCGCAAGGCCCTCAAAAAACGTCTCGAACAGCCCCGCACTCCCGGTGCCC
AACTGCACGCCGATCTTCGTGATTGCTACAAAATCAAACTGCGCAAGCAGGGATACCGTTTGGTCTATAGCGTCGAGGAC
GATGTCCTGGTCGTGTTGGTGTTGGCCATCGACAAACGCGAAGGCATGGCAGCCTACCGATCAGCAGTCGAGCGCCTGCT
CGCCGGCAAAAGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9422.80 Da
• Isoelectric Point: 4.7824

>AT30079 WP_009205795.1 NC_022357:1438671-1438922 [Sulfuricella denitrificans skB26]
MDTIFADYSISMSEFKKNPAQVLRTAGEKPVAVLNHNRPAFYMVTPKLFEALVEELADRDLVDLARQRLARKDTAIEVDV
DNI

Nucleotide

• Length: 252 bp

>AT30079 NC_022357:1438671-1438922 [Sulfuricella denitrificans skB26]
ATGGACACGATCTTCGCCGACTATTCAATCAGCATGTCCGAGTTCAAAAAAAACCCGGCGCAGGTACTGCGAACGGCAGG
CGAGAAGCCGGTTGCCGTTCTCAATCATAATCGCCCCGCTTTCTACATGGTCACCCCGAAACTCTTCGAAGCCTTGGTCG
AGGAACTGGCCGACCGGGATCTGGTGGATCTGGCGCGCCAGCGCTTGGCACGCAAGGATACGGCCATCGAGGTGGATGTT
GACAATATCTGA

Structures

Toxin

• AlphaFold DB: S6AGU9

Antitoxin

• AlphaFold DB: S6AA51