Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 446070..446548 Replicon chromosome
Accession NC_022356
Organism Haemophilus influenzae KR494

Toxin (Protein)


Gene name VapD Uniprot ID A0A112WLN3
Locus tag HIFGL_RS02165 Protein ID WP_021034684.1
Coordinates 446270..446548 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag HIFGL_RS02160 Protein ID WP_012055040.1
Coordinates 446070..446261 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIFGL_RS02135 441672..442304 + 633 WP_041175393.1 dTMP kinase -
HIFGL_RS02140 442301..443281 + 981 WP_021034681.1 DNA polymerase III subunit delta' -
HIFGL_RS02145 443317..444099 + 783 WP_021034682.1 YchF/TatD family DNA exonuclease -
HIFGL_RS02150 444126..444650 + 525 WP_005669286.1 DUF1523 family protein -
HIFGL_RS02155 444701..445999 + 1299 WP_021034683.1 hemolysin family protein -
HIFGL_RS02160 446070..446261 + 192 WP_012055040.1 DUF5397 family protein Antitoxin
HIFGL_RS02165 446270..446548 + 279 WP_021034684.1 virulence-associated protein VapD Toxin
HIFGL_RS02170 446644..447174 + 531 WP_021034685.1 hypothetical protein -
HIFGL_RS02175 447246..448745 + 1500 WP_021034686.1 fused PTS fructose transporter subunit IIA/HPr protein -
HIFGL_RS02180 448747..449688 + 942 WP_021034687.1 1-phosphofructokinase -
HIFGL_RS02185 449690..451360 + 1671 WP_021034688.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.01 Da        Isoelectric Point: 4.9670

>T30073 WP_021034684.1 NC_022356:446270-446548 [Haemophilus influenzae KR494]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNELKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Download         Length: 279 bp

>T30073 NC_022356:446270-446548 [Haemophilus influenzae KR494]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAAGGTGTTCAGCAGGCTTATACAGA
CATTGGTGCGGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATACAAATGAAGATATGGCAA
ACCTTTTTCAGGCAATGAATGAACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGTGCTTTTCGTATT
GAGCAATGGTCTGACTTCACTGACTTTATACGAAGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT30073 WP_012055040.1 NC_022356:446070-446261 [Haemophilus influenzae KR494]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT30073 NC_022356:446070-446261 [Haemophilus influenzae KR494]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGCGATGCGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGATATTTATCGCTTAT
CTCACTTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A112WLN3

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References