Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 379243..379847 Replicon chromosome
Accession NC_022356
Organism Haemophilus influenzae KR494

Toxin (Protein)


Gene name relE Uniprot ID A0A822VCP0
Locus tag HIFGL_RS01855 Protein ID WP_015701819.1
Coordinates 379243..379551 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag HIFGL_RS01860 Protein ID WP_005692346.1
Coordinates 379551..379847 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIFGL_RS01845 374415..375713 - 1299 WP_021034633.1 trigger factor -
HIFGL_RS01850 376043..379186 + 3144 WP_021034635.1 TonB-dependent receptor -
HIFGL_RS01855 379243..379551 - 309 WP_015701819.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HIFGL_RS01860 379551..379847 - 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HIFGL_RS01870 379967..380820 - 854 Protein_358 DUF3298 domain-containing protein -
HIFGL_RS01875 380839..382698 - 1860 WP_021034636.1 selenocysteine-specific translation elongation factor -
HIFGL_RS01880 382695..384080 - 1386 WP_021034637.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11919.74 Da        Isoelectric Point: 8.9408

>T30072 WP_015701819.1 NC_022356:c379551-379243 [Haemophilus influenzae KR494]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IQDKFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T30072 NC_022356:c379551-379243 [Haemophilus influenzae KR494]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACAGGATAAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT30072 WP_005692346.1 NC_022356:c379847-379551 [Haemophilus influenzae KR494]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT30072 NC_022356:c379847-379551 [Haemophilus influenzae KR494]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822VCP0

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References