Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3700475..3701149 Replicon chromosome
Accession NC_022350
Organism Mycobacterium tuberculosis str. Haarlem

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag TBHG_RS17410 Protein ID WP_003417282.1
Coordinates 3700475..3700903 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag TBHG_RS17415 Protein ID WP_003417286.1
Coordinates 3700907..3701149 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBHG_RS17385 3696297..3696698 - 402 WP_003417264.1 cytidine deaminase -
TBHG_RS17390 3696839..3697273 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
TBHG_RS17395 3697270..3697704 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
TBHG_RS17400 3697833..3699605 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
TBHG_RS17405 3699605..3700396 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
TBHG_RS17410 3700475..3700903 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
TBHG_RS17415 3700907..3701149 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
TBHG_RS17420 3701271..3701885 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
TBHG_RS17425 3701882..3702547 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
TBHG_RS17430 3702548..3703081 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
TBHG_RS17435 3703078..3703452 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
TBHG_RS17440 3703549..3704613 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T30067 WP_003417282.1 NC_022350:c3700903-3700475 [Mycobacterium tuberculosis str. Haarlem]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T30067 NC_022350:c3700903-3700475 [Mycobacterium tuberculosis str. Haarlem]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT30067 WP_003417286.1 NC_022350:c3701149-3700907 [Mycobacterium tuberculosis str. Haarlem]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT30067 NC_022350:c3701149-3700907 [Mycobacterium tuberculosis str. Haarlem]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References