30055

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2863868..2864499 Replicon chromosome
Accession NC_022350
Organism Mycobacterium tuberculosis str. Haarlem

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag TBHG_RS13375 Protein ID WP_003413174.1
Coordinates 2864122..2864499 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag TBHG_RS13370 Protein ID WP_003413167.1
Coordinates 2863868..2864125 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBHG_RS13335 2859126..2859440 + 315 WP_009937839.1 hypothetical protein -
TBHG_RS13340 2859736..2860947 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
TBHG_RS13345 2861074..2861733 + 660 WP_003900846.1 LppA family lipoprotein -
TBHG_RS13350 2861730..2862389 + 660 WP_003900847.1 hypothetical protein -
TBHG_RS13355 2862386..2863048 + 663 WP_003900848.1 hypothetical protein -
TBHG_RS13360 2863045..2863323 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
TBHG_RS13365 2863416..2863829 + 414 WP_003413164.1 PIN domain nuclease -
TBHG_RS13370 2863868..2864125 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
TBHG_RS13375 2864122..2864499 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
TBHG_RS13380 2864515..2864889 - 375 WP_003413177.1 hypothetical protein -
TBHG_RS13385 2864989..2865384 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
TBHG_RS13390 2865381..2865626 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
TBHG_RS13395 2866037..2866456 - 420 WP_003413190.1 A24 family peptidase -
TBHG_RS13400 2866468..2867277 - 810 WP_003413193.1 shikimate dehydrogenase -
TBHG_RS13405 2867274..2868527 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
TBHG_RS13410 2868520..2869032 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T30055 WP_003413174.1 NC_022350:2864122-2864499 [Mycobacterium tuberculosis str. Haarlem]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T30055 NC_022350:2864122-2864499 [Mycobacterium tuberculosis str. Haarlem]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT30055 WP_003413167.1 NC_022350:2863868-2864125 [Mycobacterium tuberculosis str. Haarlem]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT30055 NC_022350:2863868-2864125 [Mycobacterium tuberculosis str. Haarlem]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References