30050

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2367007..2367702 Replicon chromosome
Accession NC_022350
Organism Mycobacterium tuberculosis str. Haarlem

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag TBHG_RS11000 Protein ID WP_003410811.1
Coordinates 2367007..2367441 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag TBHG_RS11005 Protein ID WP_003410814.1
Coordinates 2367448..2367702 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBHG_RS10985 2363196..2364734 + 1539 WP_023637436.1 HNH endonuclease -
TBHG_RS10990 2364933..2366603 + 1671 Protein_2161 ATP-dependent helicase -
TBHG_RS10995 2366606..2367028 + 423 Protein_2162 SWIM zinc finger family protein -
TBHG_RS11000 2367007..2367441 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
TBHG_RS11005 2367448..2367702 - 255 WP_003410814.1 antitoxin Antitoxin
TBHG_RS11010 2367718..2367975 - 258 WP_003410816.1 hypothetical protein -
TBHG_RS11015 2368922..2369218 + 297 WP_003410820.1 PE family protein -
TBHG_RS11020 2369274..2370005 + 732 WP_003900467.1 PPE family protein -
TBHG_RS11025 2370545..2371291 - 747 WP_003900468.1 proteasome subunit alpha -
TBHG_RS11030 2371288..2372163 - 876 WP_003411023.1 proteasome subunit beta -
TBHG_RS11035 2372160..2372354 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T30050 WP_003410811.1 NC_022350:c2367441-2367007 [Mycobacterium tuberculosis str. Haarlem]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T30050 NC_022350:c2367441-2367007 [Mycobacterium tuberculosis str. Haarlem]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT30050 WP_003410814.1 NC_022350:c2367702-2367448 [Mycobacterium tuberculosis str. Haarlem]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT30050 NC_022350:c2367702-2367448 [Mycobacterium tuberculosis str. Haarlem]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References