30037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1687193..1687809 Replicon chromosome
Accession NC_022350
Organism Mycobacterium tuberculosis str. Haarlem

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag TBHG_RS07910 Protein ID WP_003407593.1
Coordinates 1687492..1687809 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag TBHG_RS07905 Protein ID WP_003900349.1
Coordinates 1687193..1687495 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBHG_RS07895 1683079..1684926 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
TBHG_RS07900 1684927..1687179 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
TBHG_RS07905 1687193..1687495 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
TBHG_RS07910 1687492..1687809 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
TBHG_RS07915 1687806..1688810 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
TBHG_RS07920 1688863..1690152 + 1290 WP_015345075.1 serine hydrolase -
TBHG_RS07925 1690225..1690998 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
TBHG_RS07930 1691056..1691268 - 213 WP_003898900.1 dodecin family protein -
TBHG_RS22365 1691278..1691502 - 225 WP_160522526.1 NUDIX domain-containing protein -
TBHG_RS07940 1691772..1692800 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T30037 WP_003407593.1 NC_022350:1687492-1687809 [Mycobacterium tuberculosis str. Haarlem]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T30037 NC_022350:1687492-1687809 [Mycobacterium tuberculosis str. Haarlem]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT30037 WP_003900349.1 NC_022350:1687193-1687495 [Mycobacterium tuberculosis str. Haarlem]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT30037 NC_022350:1687193-1687495 [Mycobacterium tuberculosis str. Haarlem]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References