Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 715243..715868 Replicon chromosome
Accession NC_022350
Organism Mycobacterium tuberculosis str. Haarlem

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag TBHG_RS03235 Protein ID WP_003403218.1
Coordinates 715467..715868 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag TBHG_RS03230 Protein ID WP_003403213.1
Coordinates 715243..715470 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBHG_RS03200 710422..710643 - 222 WP_003898525.1 DUF4926 domain-containing protein -
TBHG_RS03205 710785..711390 + 606 WP_003898526.1 hypothetical protein -
TBHG_RS03210 711409..713976 - 2568 WP_003900188.1 SEC-C domain-containing protein -
TBHG_RS03215 714060..714809 + 750 WP_003898528.1 hypothetical protein -
TBHG_RS03220 714806..715048 + 243 WP_003403210.1 hypothetical protein -
TBHG_RS03230 715243..715470 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
TBHG_RS03235 715467..715868 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
TBHG_RS20790 715997..716692 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
TBHG_RS20795 716689..717180 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
TBHG_RS03245 717177..718268 + 1092 WP_003906403.1 galactokinase -
TBHG_RS03255 718663..719727 + 1065 WP_003898532.1 hypothetical protein -
TBHG_RS03260 719831..720778 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T30020 WP_003403218.1 NC_022350:715467-715868 [Mycobacterium tuberculosis str. Haarlem]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T30020 NC_022350:715467-715868 [Mycobacterium tuberculosis str. Haarlem]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT30020 WP_003403213.1 NC_022350:715243-715470 [Mycobacterium tuberculosis str. Haarlem]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT30020 NC_022350:715243-715470 [Mycobacterium tuberculosis str. Haarlem]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References