Detailed information of TA system TA030003

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 117625..118190
• Replicon: chromosome
• Accession: NC_022269
• Organism: Vibrio campbellii ATCC BAA-1116

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A7MYG8
• Locus tag: M892_RS00525
• Protein ID: WP_012128211.1
• Coordinates: 117903..118190 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A7MYH0
• Locus tag: M892_RS00520
• Protein ID: WP_012128212.1
• Coordinates: 117625..117906 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M892_RS00495	113214..114368	-	1155	WP_012130156.1	IS110 family transposase	-
M892_RS00500	114541..114798	+	258	WP_012128217.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
M892_RS00505	114786..115088	+	303	WP_012128216.1	type II toxin-antitoxin system RelE/ParE family toxin	-
M892_RS28005	115126..115242	+	117	WP_080514140.1	DUF3265 domain-containing protein	-
M892_RS00510	115447..116455	-	1009	Protein_100	IS110 family transposase	-
M892_RS00515	116566..117411	-	846	Protein_101	IS4 family transposase	-
M892_RS00520	117625..117906	+	282	WP_012128212.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M892_RS00525	117903..118190	+	288	WP_012128211.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M892_RS00530	118582..119163	-	582	WP_012128210.1	DUF2913 family protein	-
M892_RS30620	119835..120389	-	555	Protein_105	IS110 family transposase	-
M892_RS00540	120500..121698	-	1199	Protein_106	IS4 family transposase	-
M892_RS00545	121980..122411	+	432	WP_012128204.1	GrpB family protein	-
M892_RS29460	122472..122630	-	159	Protein_108	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	100846..118190	17344
	-	flank	IS/Tn	-	-	121108..121422	314

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10955.64 Da
• Isoelectric Point: 5.5379

>T30003 WP_012128211.1 NC_022269:117903-118190 [Vibrio campbellii ATCC BAA-1116]
MKVVWSPLALQKLGDAAEFISLDNPVAAEHWVNEVFDKTDLLSSMPEMGRMVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRSCRQILTESDV

Nucleotide

• Length: 288 bp

>T30003 NC_022269:117903-118190 [Vibrio campbellii ATCC BAA-1116]
ATGAAAGTAGTTTGGTCACCATTAGCATTACAAAAGTTAGGAGATGCAGCCGAGTTTATTTCATTAGATAATCCAGTGGC
GGCAGAACACTGGGTCAATGAAGTCTTCGACAAAACAGACCTTCTCTCAAGTATGCCCGAGATGGGGCGAATGGTTCCTG
AGCTACCTCATACCAATTATCGCGAAATCTTGTTTGGTCACTATCGAATCATATATAGCCTCAGCCATGAAATTCGTGTT
CTTACGGTACGAAGTTGTCGTCAGATATTAACGGAAAGTGACGTGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10444.97 Da
• Isoelectric Point: 5.8719

>AT30003 WP_012128212.1 NC_022269:117625-117906 [Vibrio campbellii ATCC BAA-1116]
MSRIHFDQDIQTLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGISN
EDARAQVLGRLKK

Nucleotide

• Length: 282 bp

>AT30003 NC_022269:117625-117906 [Vibrio campbellii ATCC BAA-1116]
ATGAGTCGTATCCATTTTGATCAAGATATTCAGACTTTGTCTGAATTTCGTGCTGGCGTGACATCATTCATTAAACAGAT
TAACGAAACTCGCAGACCGCTAGTAATCACACAGCGCGGTAAAGGTGTTGCGGTTGTCCTTGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAGATCGAGTTACTAGAAGAAATGCGTACTGCTGAAGCTCAGTTAGCGTCAGGTTTAGGTATTTCCAAT
GAAGACGCTCGTGCTCAAGTGTTGGGACGTCTTAAGAAATGA

Structures

Toxin

• AlphaFold DB: A7MYG8

Antitoxin

• AlphaFold DB: A7MYH0