Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 114541..115088 Replicon chromosome
Accession NC_022269
Organism Vibrio campbellii ATCC BAA-1116

Toxin (Protein)


Gene name relE Uniprot ID A0A240EQK2
Locus tag M892_RS00505 Protein ID WP_012128216.1
Coordinates 114786..115088 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A7MSI1
Locus tag M892_RS00500 Protein ID WP_012128217.1
Coordinates 114541..114798 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M892_RS00480 110301..111260 - 960 WP_012128222.1 thioredoxin-disulfide reductase -
M892_RS00485 111439..112467 - 1029 WP_012129842.1 IS630 family transposase -
M892_RS00490 112527..112712 - 186 Protein_95 IS110 family transposase -
M892_RS00495 113214..114368 - 1155 WP_012130156.1 IS110 family transposase -
M892_RS00500 114541..114798 + 258 WP_012128217.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M892_RS00505 114786..115088 + 303 WP_012128216.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M892_RS28005 115126..115242 + 117 WP_080514140.1 DUF3265 domain-containing protein -
M892_RS00510 115447..116455 - 1009 Protein_100 IS110 family transposase -
M892_RS00515 116566..117411 - 846 Protein_101 IS4 family transposase -
M892_RS00520 117625..117906 + 282 WP_012128212.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M892_RS00525 117903..118190 + 288 WP_012128211.1 type II toxin-antitoxin system RelE/ParE family toxin -
M892_RS00530 118582..119163 - 582 WP_012128210.1 DUF2913 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 100846..118190 17344


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11699.59 Da        Isoelectric Point: 5.1765

>T30002 WP_012128216.1 NC_022269:114786-115088 [Vibrio campbellii ATCC BAA-1116]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDSDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T30002 NC_022269:114786-115088 [Vibrio campbellii ATCC BAA-1116]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCAGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACAGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTACGTAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9548.06 Da        Isoelectric Point: 7.3177

>AT30002 WP_012128217.1 NC_022269:114541-114798 [Vibrio campbellii ATCC BAA-1116]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALAGGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT30002 NC_022269:114541-114798 [Vibrio campbellii ATCC BAA-1116]
ATGAAAGTAGAACTAGTTACATCACTCAAGCGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGGCGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A240EQK2

Antitoxin

Source ID Structure
AlphaFold DB A7MSI1

References