Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3437563..3439320 Replicon chromosome
Accession NC_022247
Organism Variovorax paradoxus B4

Toxin (Protein)


Gene name doc Uniprot ID T1XDE1
Locus tag VAPA_RS16060 Protein ID WP_021007814.1
Coordinates 3438445..3439320 (-) Length 292 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID T1XCQ0
Locus tag VAPA_RS16055 Protein ID WP_021007813.1
Coordinates 3437563..3438399 (-) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VAPA_RS16035 3432730..3434208 - 1479 WP_021007809.1 aldehyde dehydrogenase -
VAPA_RS16040 3434219..3435007 - 789 WP_196232575.1 aspartate dehydrogenase -
VAPA_RS16045 3435019..3436731 - 1713 WP_021007811.1 thiamine pyrophosphate-binding protein -
VAPA_RS16050 3436724..3437551 - 828 WP_041946480.1 SDR family oxidoreductase -
VAPA_RS16055 3437563..3438399 - 837 WP_021007813.1 IclR family transcriptional regulator Antitoxin
VAPA_RS16060 3438445..3439320 - 876 WP_021007814.1 alpha/beta fold hydrolase Toxin
VAPA_RS16065 3439332..3439880 - 549 WP_021007815.1 cupin domain-containing protein -
VAPA_RS16070 3439910..3440725 - 816 WP_021007816.1 SDR family oxidoreductase -
VAPA_RS16075 3440732..3441715 - 984 WP_021007817.1 tripartite tricarboxylate transporter substrate binding protein -
VAPA_RS16080 3441892..3443148 - 1257 WP_021007818.1 D-amino acid dehydrogenase -
VAPA_RS16085 3443207..3444238 - 1032 WP_021007819.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-283)

Antitoxin

Transcription regulator IclR, N-terminal

(20-69)


Sequences

Toxin        


Download         Length: 292 a.a.        Molecular weight: 29911.34 Da        Isoelectric Point: 7.2226

>T30001 WP_021007814.1 NC_022247:c3439320-3438445 [Variovorax paradoxus B4]
MNDAIATNALTSLPASELALLEARFPARAVPVGGGAVVSVRERGAGPAIVCLHGIGSGAASWLNVALLLAPQARVVAWDA
PGYGASTPLSAAQPSAADYAQRLHGLLDALDVQSCVLVGHSLGALTAASAARKDSALASRVRRLVLISPAAGYGAPQREE
ARRKVRAERLATLDELGIAGMAAKRAGRLVSDSAGELARQWVQWNMAQLNDGGYRQAVELLCGADLLADLPPAMPVRVAC
GALDVVTTPEACAEVARRCGVPLESIADAGHASYVERPQAVAALLREVLAA

Download         Length: 876 bp

>T30001 NC_022247:c3439320-3438445 [Variovorax paradoxus B4]
ATGAACGACGCCATCGCCACCAACGCGCTGACCTCCTTGCCCGCTTCCGAGCTGGCGCTGCTGGAGGCCCGCTTTCCGGC
GCGCGCCGTGCCGGTCGGCGGCGGTGCCGTGGTGTCGGTGCGCGAACGCGGCGCGGGCCCGGCCATCGTCTGCCTGCACG
GCATCGGCTCGGGCGCGGCCTCGTGGCTCAACGTTGCCTTGCTGCTTGCGCCGCAGGCCCGCGTGGTCGCATGGGATGCG
CCGGGCTATGGTGCATCGACGCCGCTCTCGGCCGCACAACCCTCCGCGGCGGACTATGCGCAGCGGCTGCACGGCCTGCT
CGATGCGCTCGACGTCCAGTCCTGCGTGCTGGTCGGCCATTCGCTTGGTGCGCTCACTGCCGCGTCTGCCGCGCGCAAGG
ATTCGGCCCTGGCTTCGCGCGTCCGCCGCCTCGTGCTCATCAGCCCCGCGGCCGGCTATGGTGCCCCGCAGCGCGAGGAA
GCCCGCCGCAAGGTGCGCGCCGAGCGCCTCGCCACGCTCGACGAACTCGGCATCGCCGGCATGGCCGCGAAGCGTGCGGG
CCGGCTCGTGTCCGACAGCGCCGGCGAACTCGCGCGCCAGTGGGTGCAATGGAACATGGCGCAGCTCAACGACGGCGGCT
ACCGGCAGGCCGTCGAGCTGCTGTGCGGCGCCGACCTGCTGGCCGACCTGCCACCCGCCATGCCGGTGCGCGTGGCCTGC
GGCGCGCTCGATGTCGTCACCACGCCCGAGGCCTGCGCCGAAGTCGCGCGCCGGTGCGGCGTGCCGCTCGAATCGATTGC
CGATGCCGGGCACGCCAGCTACGTGGAGCGGCCGCAAGCCGTTGCCGCACTGCTGCGCGAAGTGCTGGCCGCCTGA

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 30628.99 Da        Isoelectric Point: 5.7786

>AT30001 WP_021007813.1 NC_022247:c3438399-3437563 [Variovorax paradoxus B4]
MATNDNETMEEGGERYNVPALERGLRVLCEFSRESRTLSAPELARRLDLPRSTVFRLLTTLENMGFLERAEGGRDYRLGL
AVLRLGFEYLASLELTQLGAPLLNRLCDELRTPCNLVVRDGRSIVYVAKVAPPTPFASSVTVGTRLPAHATVLGRVLLED
LTLPQLRALYPEDRLETFSPSTPKTVSELFDMVQADRSRGYVLGEGFFESNISSIAAPVRDHSGHIVAALGATITSGHIE
ENRMDEMVLRVRSTAEEISGLLNYSPARASKVVPLRSA

Download         Length: 837 bp

>AT30001 NC_022247:c3438399-3437563 [Variovorax paradoxus B4]
ATGGCCACCAACGACAACGAGACAATGGAAGAGGGCGGCGAGCGCTACAACGTGCCGGCGCTCGAGCGCGGCCTGCGCGT
GCTGTGCGAATTCAGCCGGGAGAGCCGCACGCTCTCCGCGCCCGAACTGGCTCGCCGCCTCGACCTGCCGCGCTCGACCG
TGTTCCGGCTTCTCACCACGCTGGAGAACATGGGCTTCCTCGAGCGCGCCGAAGGCGGGCGCGACTACCGCCTGGGCCTG
GCCGTGCTGCGCCTCGGCTTCGAATACCTGGCCTCGCTCGAGCTCACGCAGCTGGGCGCGCCGCTGCTCAACCGCCTGTG
CGACGAGCTGCGCACGCCCTGCAACCTGGTGGTGCGCGACGGCCGTTCCATCGTCTATGTCGCCAAGGTGGCGCCGCCCA
CGCCGTTCGCGAGCTCGGTCACCGTGGGCACGCGCCTGCCGGCCCATGCCACCGTGCTCGGCCGCGTGCTGCTCGAAGAC
CTCACGCTGCCGCAGCTGCGCGCGCTCTACCCCGAGGACAGGCTCGAGACCTTCTCGCCGAGCACGCCCAAGACCGTGAG
CGAGCTGTTCGACATGGTGCAGGCCGACCGCTCGCGTGGCTACGTGCTGGGCGAAGGCTTCTTCGAATCGAACATCTCCA
GTATCGCGGCGCCGGTGCGCGACCACAGCGGCCACATCGTGGCGGCGCTGGGCGCCACCATCACCTCGGGCCACATCGAG
GAGAACCGCATGGACGAGATGGTGCTGCGCGTGCGCAGCACGGCCGAAGAAATCTCGGGCCTGCTGAACTATTCGCCCGC
GCGCGCCAGCAAGGTGGTGCCGCTTCGCAGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1XDE1

Antitoxin

Source ID Structure
AlphaFold DB T1XCQ0

References