Detailed information of TA system TA029994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1662515..1663201
• Replicon: chromosome
• Accession: NC_022240
• Organism: Neisseria gonorrhoeae MS11

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: NGFG_RS09015
• Protein ID: WP_003689143.1
• Coordinates: 1663019..1663201 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: NGFG_RS09010
• Protein ID: WP_003691454.1
• Coordinates: 1662515..1662916 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NGFG_RS08960	1657647..1657879	-	233	Protein_1671	hypothetical protein	-
NGFG_RS08965	1658258..1658749	-	492	WP_020997393.1	siphovirus Gp157 family protein	-
NGFG_RS08970	1658746..1658928	-	183	WP_003691535.1	hypothetical protein	-
NGFG_RS08975	1659068..1659754	-	687	WP_010951053.1	hypothetical protein	-
NGFG_RS08980	1659823..1659984	-	162	WP_003693867.1	hypothetical protein	-
NGFG_RS08985	1659981..1660256	-	276	WP_003694990.1	hypothetical protein	-
NGFG_RS08990	1660409..1660741	-	333	WP_003695500.1	hypothetical protein	-
NGFG_RS08995	1660882..1661082	-	201	WP_003695499.1	hypothetical protein	-
NGFG_RS09000	1661323..1661739	-	417	WP_003695497.1	hypothetical protein	-
NGFG_RS09005	1661748..1662332	-	585	WP_003693477.1	SocA family protein	-
NGFG_RS09010	1662515..1662916	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
NGFG_RS09015	1663019..1663201	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
NGFG_RS09020	1663371..1664189	-	819	WP_017147226.1	DUF3037 domain-containing protein	-
NGFG_RS09025	1664464..1665219	-	756	WP_003693472.1	LexA family transcriptional regulator	-
NGFG_RS13600	1665359..1665544	+	186	WP_002238713.1	Cro/Cl family transcriptional regulator	-
NGFG_RS09030	1665633..1665788	+	156	WP_003689578.1	hypothetical protein	-
NGFG_RS09035	1665765..1665953	-	189	WP_003696008.1	hypothetical protein	-
NGFG_RS09040	1666126..1666389	+	264	WP_017147285.1	helix-turn-helix domain-containing protein	-
NGFG_RS09045	1666386..1667285	+	900	WP_003695001.1	replication protein	-
NGFG_RS09050	1667300..1668082	+	783	WP_003695002.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1647000..1680800	33800

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T29994 WP_003689143.1 NC_022240:c1663201-1663019 [Neisseria gonorrhoeae MS11]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T29994 NC_022240:c1663201-1663019 [Neisseria gonorrhoeae MS11]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT29994 WP_003691454.1 NC_022240:c1662916-1662515 [Neisseria gonorrhoeae MS11]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT29994 NC_022240:c1662916-1662515 [Neisseria gonorrhoeae MS11]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2