Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 949016..949671 Replicon chromosome
Accession NC_022240
Organism Neisseria gonorrhoeae MS11

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NGFG_RS05090 Protein ID WP_003691083.1
Coordinates 949016..949435 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NGFG_RS05095 Protein ID WP_003688410.1
Coordinates 949435..949671 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGFG_RS05070 944250..945791 - 1542 WP_003688418.1 multidrug efflux MFS transporter -
NGFG_RS05075 945939..946718 + 780 WP_003688416.1 (Fe-S)-binding protein -
NGFG_RS05080 946715..947416 + 702 WP_003688414.1 lactate utilization protein C -
NGFG_RS05085 947413..948867 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
NGFG_RS05090 949016..949435 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NGFG_RS05095 949435..949671 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NGFG_RS14395 949877..950074 - 198 WP_033910354.1 IS3 family transposase -
NGFG_RS05100 950119..950697 - 579 WP_003688041.1 IS3 family transposase -
NGFG_RS05105 950702..951130 - 429 WP_003701165.1 helix-turn-helix domain-containing protein -
NGFG_RS05110 951342..951728 + 387 Protein_965 IS110 family transposase -
NGFG_RS05115 952111..953001 - 891 WP_003688409.1 succinate--CoA ligase subunit alpha -
NGFG_RS05120 953012..954178 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
NGFG_RS05125 954250..954537 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T29993 WP_003691083.1 NC_022240:c949435-949016 [Neisseria gonorrhoeae MS11]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T29993 NC_022240:c949435-949016 [Neisseria gonorrhoeae MS11]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT29993 WP_003688410.1 NC_022240:c949671-949435 [Neisseria gonorrhoeae MS11]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT29993 NC_022240:c949671-949435 [Neisseria gonorrhoeae MS11]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References