Detailed information of TA system TA029992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2137677..2138284
• Replicon: chromosome
• Accession: NC_022239
• Organism: Streptococcus anginosus C238

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: I0S7M8
• Locus tag: SANR_RS10470
• Protein ID: WP_003038349.1
• Coordinates: 2137677..2137868 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: I0S7P0
• Locus tag: SANR_RS10475
• Protein ID: WP_003038371.1
• Coordinates: 2137904..2138284 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SANR_RS11780	2132986..2133153	+	168	WP_003038324.1	hypothetical protein	-
SANR_RS10430	2133496..2133774	+	279	WP_003027794.1	hypothetical protein	-
SANR_RS11785	2133771..2133947	+	177	WP_003027795.1	hypothetical protein	-
SANR_RS10435	2133937..2134173	+	237	WP_003038392.1	hypothetical protein	-
SANR_RS10440	2134170..2134505	+	336	WP_003038362.1	hypothetical protein	-
SANR_RS10445	2134507..2134776	+	270	WP_003038376.1	hypothetical protein	-
SANR_RS10450	2134785..2135591	+	807	WP_003038339.1	phage replisome organizer N-terminal domain-containing protein	-
SANR_RS10455	2135606..2136457	+	852	WP_020999881.1	ATP-binding protein	-
SANR_RS10460	2136706..2137146	+	441	WP_003038422.1	ArpU family transcriptional regulator	-
SANR_RS10470	2137677..2137868	+	192	WP_003038349.1	type II toxin-antitoxin system HicA family toxin	Toxin
SANR_RS10475	2137904..2138284	+	381	WP_003038371.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SANR_RS10480	2138836..2139276	+	441	WP_003032335.1	LytTR family transcriptional regulator	-
SANR_RS10485	2139273..2139731	+	459	WP_003038399.1	DUF3021 domain-containing protein	-
SANR_RS10490	2139919..2142480	-	2562	WP_020999883.1	DNA mismatch repair protein MutS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2125516..2138284	12768

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7192.29 Da
• Isoelectric Point: 8.6749

>T29992 WP_003038349.1 NC_022239:2137677-2137868 [Streptococcus anginosus C238]
MPLTGKEMAKLAEKNGWVEIRQNGSHHHFKHEDFDYIVTIPIHGNKDLGRGLESKILKDLGLK

Nucleotide

• Length: 192 bp

>T29992 NC_022239:2137677-2137868 [Streptococcus anginosus C238]
ATGCCACTTACAGGAAAAGAAATGGCAAAGCTAGCCGAGAAAAATGGTTGGGTAGAAATCCGACAGAACGGCAGCCATCA
CCATTTCAAACATGAAGATTTTGATTATATAGTGACTATCCCAATCCATGGAAACAAGGATTTAGGAAGAGGGCTAGAAA
GCAAAATCCTGAAAGATTTGGGGCTGAAATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14150.14 Da
• Isoelectric Point: 4.5235

>AT29992 WP_003038371.1 NC_022239:2137904-2138284 [Streptococcus anginosus C238]
MLKSYPAIFHKEEDGSYWVEFPEFGGGTQGANVEEALKNAREMLESVLAAYIDEGLDMPKPSDIMALTVKDGFVSMIQAD
PTPFIRNNKAVRKNVTVPEWLVRLADREKVNYSEVLTQALETKLQA

Nucleotide

• Length: 381 bp

>AT29992 NC_022239:2137904-2138284 [Streptococcus anginosus C238]
ATGTTAAAATCATATCCAGCAATTTTTCATAAAGAGGAAGACGGTTCTTATTGGGTAGAATTTCCAGAGTTTGGAGGAGG
CACACAAGGGGCAAATGTTGAAGAAGCCTTGAAAAATGCCCGTGAAATGCTTGAGAGTGTTTTAGCTGCTTACATAGACG
AAGGATTAGATATGCCAAAGCCTAGCGACATCATGGCTTTAACCGTTAAAGACGGCTTTGTTAGCATGATACAAGCAGAC
CCTACCCCGTTTATTCGCAACAATAAAGCCGTTAGAAAGAATGTGACTGTCCCTGAATGGCTAGTAAGATTAGCGGATCG
TGAAAAAGTAAATTATTCTGAGGTGCTAACTCAAGCCCTAGAAACAAAGTTACAAGCCTAG

Structures

Toxin

• AlphaFold DB: I0S7M8

Antitoxin

• AlphaFold DB: I0S7P0