Detailed information of TA system TA029991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1210888..1212152
• Replicon: chromosome
• Accession: NC_022239
• Organism: Streptococcus anginosus C238

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: I0SCS6
• Locus tag: SANR_RS06000
• Protein ID: WP_003036796.1
• Coordinates: 1210888..1211676 (-)
• Length: 263 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: SANR_RS06005
• Protein ID: WP_003024006.1
• Coordinates: 1211676..1212152 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SANR_RS05975	1205920..1206279	-	360	WP_003036844.1	hypothetical protein	-
SANR_RS05980	1206671..1207525	-	855	WP_003036855.1	hypothetical protein	-
SANR_RS05985	1207532..1207996	-	465	WP_041791155.1	Mov34/MPN/PAD-1 family protein	-
SANR_RS05990	1207974..1209740	-	1767	WP_020999636.1	ThiF family adenylyltransferase	-
SANR_RS05995	1209749..1210785	-	1037	Protein_1149	hypothetical protein	-
SANR_RS06000	1210888..1211676	-	789	WP_003036796.1	zeta toxin family protein	Toxin
SANR_RS06005	1211676..1212152	-	477	WP_003024006.1	helix-turn-helix domain-containing protein	Antitoxin
SANR_RS06010	1212222..1212509	-	288	WP_041791158.1	hypothetical protein	-
SANR_RS06015	1212553..1212942	-	390	WP_003036708.1	hypothetical protein	-
SANR_RS06020	1212939..1213166	-	228	WP_003036737.1	hypothetical protein	-
SANR_RS06025	1213221..1214309	-	1089	WP_020999638.1	toprim domain-containing protein	-
SANR_RS06030	1214348..1214986	-	639	WP_003036847.1	hypothetical protein	-
SANR_RS11190	1215126..1216124	+	999	WP_003036688.1	D-Ala D-Ala ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (31-217)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 263 a.a.
• Molecular weight: 30088.19 Da
• Isoelectric Point: 7.1606

>T29991 WP_003036796.1 NC_022239:c1211676-1210888 [Streptococcus anginosus C238]
MRLEEFSEDEFQKALQRTIRSLTLTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLAL
QEKYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRKTAQLLRKKGYHISLAVIGTKPELSYLSTLIRY
EELYTINPNQARATPKEHHDGIVEHLVDNLRELENDKLFDRIQIYQRDRTCIYDSETDEISAATVLQECLFGKWSKVEEE
MLKVGQERLRDLCWKNGSSGIF

Nucleotide

• Length: 789 bp

>T29991 NC_022239:c1211676-1210888 [Streptococcus anginosus C238]
ATGAGACTGGAAGAATTTAGTGAGGATGAATTTCAGAAAGCCTTACAGCGAACGATTCGATCTCTAACTCTAACTCGTGG
AAAGACGATTCCAGACCAACCGAAAGCCATTTTGCTTGGAGGTCAAAGCGGAGCTGGTAAGACGACTATTCATCGAATTA
AGCAAAAAGAATTTCAAGGGAATATCATTATCATTGACGGTGATAGCTACCGTTCTCAGCACCCAAATTACTTAGCTCTG
CAAGAAAAGTATGGTAAAGATAGTGTGGATTATACAAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGATGAACT
CAGTACACAAGGCTATCATTTGTTGATTGAAGGGACTTTGCGAACCACTCAAGTCCCACGGAAGACTGCTCAATTACTAC
GAAAAAAAGGCTACCATATTTCTTTGGCTGTGATTGGCACCAAACCAGAACTTTCCTATCTCAGTACCTTGATTCGTTAT
GAGGAACTTTACACAATAAATCCTAATCAGGCCAGAGCAACCCCTAAAGAACATCATGATGGTATTGTAGAGCATTTGGT
TGATAACCTAAGAGAGTTAGAAAACGATAAACTCTTTGACCGCATTCAAATTTACCAAAGAGATAGGACTTGTATTTACG
ATTCTGAAACGGATGAGATTTCCGCAGCAACAGTTCTTCAAGAATGCCTTTTCGGAAAATGGAGTAAGGTTGAGGAGGAG
ATGTTGAAAGTGGGACAGGAACGGTTGAGAGATTTGTGTTGGAAGAACGGTAGTAGTGGTATCTTCTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18260.64 Da
• Isoelectric Point: 4.3971

>AT29991 WP_003024006.1 NC_022239:c1212152-1211676 [Streptococcus anginosus C238]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEDKMLTPLEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLDTVYHRVVA

Nucleotide

• Length: 477 bp

>AT29991 NC_022239:c1212152-1211676 [Streptococcus anginosus C238]
ATGATTGGAGATAATATTAAGTCCTTACGAAAAACTCATGATTTAACCCAGCCAGAATTCGCAAAAATTGTTGGGATTTC
ACGCAATAGCCTAAGTCGATATGAAAATGGAACTAGTTCTGTTTCAACAGAACTCATCGACCGAATTTGTCAGAAATTTA
ATGTTTCATACGTTGATATTGTAGGGGAGGACAAAATGCTAACACCCCTTGAAGATTATCAATTGACCTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCGGCCATTTTATCCCAACTCTATCGCTACCAAGATAGTCAAGATATTGCTTTTGATGACGA
AACCAATCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCCATACAAAGATTTACCTTGTTGATACTTTCGATG
AAATAGAGCGTTATAATGGCTATTTAGACGGTATAGAGCGGATGTTAGACACGGTGTATCATCGGGTGGTGGCTTGA

Structures

Toxin

• AlphaFold DB: I0SCS6