Detailed information of TA system TA029990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 142057..142608
• Replicon: chromosome
• Accession: NC_022239
• Organism: Streptococcus anginosus C238

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I0SIJ7
• Locus tag: SANR_RS00835
• Protein ID: WP_003034637.1
• Coordinates: 142057..142335 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I0SII5
• Locus tag: SANR_RS00840
• Protein ID: WP_003034600.1
• Coordinates: 142336..142608 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SANR_RS00800	138164..138418	-	255	WP_003034719.1	Txe/YoeB family addiction module toxin	-
SANR_RS00805	138411..138677	-	267	WP_003034688.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
SANR_RS00810	138941..140599	-	1659	WP_003034653.1	cell division protein FtsK	-
SANR_RS00815	140606..141016	-	411	WP_003034661.1	DUF961 family protein	-
SANR_RS00820	141039..141353	-	315	WP_000406626.1	hypothetical protein	-
SANR_RS00825	141468..141695	-	228	WP_003034721.1	hypothetical protein	-
SANR_RS00830	141692..141928	-	237	WP_003034655.1	hypothetical protein	-
SANR_RS00835	142057..142335	-	279	WP_003034637.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SANR_RS00840	142336..142608	-	273	WP_003034600.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SANR_RS00845	143281..143643	+	363	WP_003034723.1	helix-turn-helix domain-containing protein	-
SANR_RS00850	143650..144501	+	852	WP_003034663.1	ImmA/IrrE family metallo-endopeptidase	-
SANR_RS00855	144521..144874	-	354	WP_003034700.1	hypothetical protein	-
SANR_RS00860	145121..145648	+	528	WP_003034714.1	hypothetical protein	-
SANR_RS00865	145675..146193	+	519	WP_003034614.1	hypothetical protein	-
SANR_RS00870	146186..147208	+	1023	WP_003034698.1	radical SAM protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	126809..149107	22298

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10876.72 Da
• Isoelectric Point: 8.0384

>T29990 WP_003034637.1 NC_022239:c142335-142057 [Streptococcus anginosus C238]
MYQVKFTSAFKKSYKRIKKRGLEIALLDEVIEKLRLGQTLEEKYRDHELKGNFVGFRECHIKPDWLLIYLIEDDILTLTL
ADTGSHADLFKM

Nucleotide

• Length: 279 bp

>T29990 NC_022239:c142335-142057 [Streptococcus anginosus C238]
ATGTATCAAGTCAAGTTTACCTCTGCTTTTAAAAAGAGCTATAAACGGATTAAAAAGCGAGGCTTAGAGATAGCACTCTT
AGATGAAGTGATTGAAAAACTCCGTCTAGGTCAGACACTAGAAGAAAAATACCGTGACCATGAACTCAAAGGAAACTTTG
TTGGCTTTAGGGAATGTCACATCAAGCCAGATTGGCTCTTGATTTATCTGATTGAAGACGATATTTTGACATTGACTTTA
GCTGATACAGGCAGTCATGCGGATTTGTTTAAGATGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9932.42 Da
• Isoelectric Point: 5.0337

>AT29990 WP_003034600.1 NC_022239:c142608-142336 [Streptococcus anginosus C238]
MATVPTQIRINETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEALAEAKRISRDETVASYDN
LADLKKALEV

Nucleotide

• Length: 273 bp

>AT29990 NC_022239:c142608-142336 [Streptococcus anginosus C238]
ATGGCAACTGTACCAACTCAAATTCGGATTAATGAAACTGTCAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGGAT
GGATATGTCTAGTGCAGTCAATATTTTTCTTCGGCAATGTCTATTGCGTGGTGGACTTCCTTTCACGGTTGAAGTTCCCA
ATTATAGCCAAAAGACCTTAGAAGCTCTGGCAGAAGCTAAACGAATCTCTCGTGATGAAACGGTCGCTTCTTATGACAAT
CTAGCAGATTTAAAGAAGGCTCTGGAAGTTTAG

Structures

Toxin

• AlphaFold DB: I0SIJ7

Antitoxin

• AlphaFold DB: I0SII5