29987

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 670952..672189 Replicon chromosome
Accession NC_022237
Organism Streptococcus intermedius C270

Toxin (Protein)


Gene name pezT Uniprot ID A0A3R9KTY4
Locus tag SII_RS03390 Protein ID WP_020998538.1
Coordinates 671428..672189 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A3R9RM37
Locus tag SII_RS03385 Protein ID WP_041823159.1
Coordinates 670952..671428 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SII_RS03345 667207..667491 + 285 WP_020998532.1 hypothetical protein -
SII_RS03350 667505..667801 + 297 WP_041823157.1 hypothetical protein -
SII_RS03355 667815..668012 - 198 WP_001842085.1 hypothetical protein -
SII_RS03360 668172..668813 + 642 WP_020998534.1 hypothetical protein -
SII_RS03365 668823..669908 + 1086 WP_020998535.1 toprim domain-containing protein -
SII_RS03370 669959..670192 + 234 WP_000152419.1 hypothetical protein -
SII_RS03375 670189..670572 + 384 WP_020998536.1 hypothetical protein -
SII_RS03380 670610..670882 + 273 WP_020998537.1 hypothetical protein -
SII_RS03385 670952..671428 + 477 WP_041823159.1 helix-turn-helix domain-containing protein Antitoxin
SII_RS03390 671428..672189 + 762 WP_020998538.1 zeta toxin family protein Toxin
SII_RS03395 672217..674715 + 2499 WP_020998539.1 AAA family ATPase -
SII_RS03400 675639..675995 + 357 WP_020998540.1 hypothetical protein -
SII_RS03405 676000..676365 + 366 WP_000401235.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(M) - 642560..709668 67108


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 28955.00 Da        Isoelectric Point: 7.1307

>T29987 WP_020998538.1 NC_022237:671428-672189 [Streptococcus intermedius C270]
MEIQDYADSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKETAQLLKSKGYEVQLALIATKPKLSYLSTLIRYEE
LYSINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTAPAADILQELLFGEWSQVEKEML
KVGEKRLNELLEK

Download         Length: 762 bp

>T29987 NC_022237:671428-672189 [Streptococcus intermedius C270]
ATGGAAATCCAAGATTATGCTGATAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCAATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATACACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACGATTGACGTTCCAAAGGAAACAGCACAACTCTTGAAAAGTA
AGGGATATGAAGTACAATTAGCTTTGATTGCGACAAAGCCTAAACTGTCCTATCTGAGCACCCTTATCCGTTATGAAGAA
CTGTATTCTATCAATCCAAATCAAGCTCGTGCAACACCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAGCTCCAGCAGCAGATATTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAGGTAGAGAAAGAGATGTTG
AAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18258.73 Da        Isoelectric Point: 4.4977

>AT29987 WP_041823159.1 NC_022237:670952-671428 [Streptococcus intermedius C270]
MIGKNIKSLRKSHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTKIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT29987 NC_022237:670952-671428 [Streptococcus intermedius C270]
ATGATTGGAAAGAACATAAAATCCTTACGTAAATCACATGACTTAACACAACCTGAATTTGCCCGAATTATAGGAATTTC
TCGAAATAGTTTGAGTCGTTATGAAAATGGCACTAGTTCAGTCTCTACGGAACTAATAGATATCATCTGCCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATTTATTATCACGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAAAATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGGTATAGCGGCTATTTGGATGGAATTGAACGTATGTTGGAGATATCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9KTY4

Antitoxin

Source ID Structure
AlphaFold DB A0A3R9RM37

References