Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 12546..13126 Replicon chromosome
Accession NC_022234
Organism Variovorax paradoxus B4

Toxin (Protein)


Gene name vapC Uniprot ID T1XKE1
Locus tag VAPA_RS27130 Protein ID WP_021003408.1
Coordinates 12546..12926 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0H2LXX3
Locus tag VAPA_RS27135 Protein ID WP_041946638.1
Coordinates 12923..13126 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VAPA_RS34595 7979..8167 - 189 WP_155248127.1 hypothetical protein -
VAPA_RS27120 8175..8693 - 519 WP_021003406.1 Lrp/AsnC family transcriptional regulator -
VAPA_RS27125 8786..12388 + 3603 WP_021003407.1 indolepyruvate ferredoxin oxidoreductase family protein -
VAPA_RS27130 12546..12926 - 381 WP_021003408.1 type II toxin-antitoxin system VapC family toxin Toxin
VAPA_RS27135 12923..13126 - 204 WP_041946638.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
VAPA_RS27140 13350..14204 + 855 WP_021003409.1 AraC family transcriptional regulator -
VAPA_RS27145 14244..14948 + 705 WP_021003410.1 B3/4 domain-containing protein -
VAPA_RS27150 15294..15527 + 234 Protein_14 LysR family transcriptional regulator -
VAPA_RS27155 15566..16378 - 813 WP_021003412.1 enoyl-CoA hydratase -
VAPA_RS27160 16389..17828 - 1440 WP_021003413.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13938.29 Da        Isoelectric Point: 6.0641

>T29984 WP_021003408.1 NC_022234:c12926-12546 [Variovorax paradoxus B4]
VNPVLVDTSVWVDHFRARNAALEQLLELDKVLMHPMVLGELACGTPPSRTQTLGYLQHLRQMQQANLREVLVLIETERLF
GVGCGLVDLTLLASTLMTPGAELWTLDRCLGDLAQRFAVAHRPVGP

Download         Length: 381 bp

>T29984 NC_022234:c12926-12546 [Variovorax paradoxus B4]
GTGAACCCTGTCCTGGTCGACACCTCGGTCTGGGTTGACCACTTTCGCGCCCGCAATGCCGCCTTGGAGCAATTGCTCGA
ACTGGATAAGGTATTGATGCATCCGATGGTTCTGGGGGAACTTGCGTGCGGCACTCCGCCTTCGCGCACGCAGACGCTTG
GCTATCTCCAGCACCTGCGGCAGATGCAGCAGGCGAACTTGCGGGAGGTGCTCGTCCTGATTGAGACGGAACGCCTGTTT
GGAGTGGGGTGCGGGCTCGTCGACCTGACTCTGCTGGCATCCACGCTCATGACACCAGGGGCCGAGTTGTGGACCTTGGA
CAGGTGCCTGGGCGACTTGGCACAGCGATTTGCAGTGGCCCACCGCCCGGTCGGGCCTTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7304.43 Da        Isoelectric Point: 10.4516

>AT29984 WP_041946638.1 NC_022234:c13126-12923 [Variovorax paradoxus B4]
MRTTVTIEDALYEEALAVADPSMDKADLFREAIKTFVRVQAAKRLAALGGRAPKMPDVPRRRGGTSS

Download         Length: 204 bp

>AT29984 NC_022234:c13126-12923 [Variovorax paradoxus B4]
ATGAGAACTACTGTCACCATTGAAGACGCTCTCTACGAGGAAGCGCTCGCAGTTGCGGACCCCAGCATGGACAAAGCGGA
CCTCTTCAGGGAAGCGATCAAAACCTTCGTGAGGGTGCAAGCGGCCAAGCGACTTGCAGCCCTCGGGGGGCGTGCGCCCA
AGATGCCCGATGTGCCCCGCCGCCGCGGAGGCACGAGTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1XKE1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2LXX3

References