Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2095526..2096040 Replicon chromosome
Accession NC_022226
Organism Staphylococcus aureus subsp. aureus CN1

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag SAKOR_RS10560 Protein ID WP_000581792.1
Coordinates 2095526..2095735 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag SAKOR_RS10565 Protein ID WP_000138932.1
Coordinates 2095747..2096040 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAKOR_RS10540 2091034..2092392 - 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SAKOR_RS10545 2092407..2093477 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
SAKOR_RS10550 2093795..2094997 + 1203 WP_020978293.1 rod shape-determining protein RodA -
SAKOR_RS10555 2095261..2095398 - 138 WP_000828354.1 hypothetical protein -
SAKOR_RS10560 2095526..2095735 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
SAKOR_RS10565 2095747..2096040 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAKOR_RS10570 2096206..2097691 + 1486 Protein_1993 cardiolipin synthase -
SAKOR_RS10575 2097719..2098366 + 648 WP_001187630.1 HD domain-containing protein -
SAKOR_RS10580 2098838..2099710 - 873 WP_000725802.1 membrane protein insertase YidC -
SAKOR_RS10585 2099796..2100437 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T29977 WP_000581792.1 NC_022226:c2095735-2095526 [Staphylococcus aureus subsp. aureus CN1]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T29977 NC_022226:c2095735-2095526 [Staphylococcus aureus subsp. aureus CN1]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT29977 WP_000138932.1 NC_022226:c2096040-2095747 [Staphylococcus aureus subsp. aureus CN1]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT29977 NC_022226:c2096040-2095747 [Staphylococcus aureus subsp. aureus CN1]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References