Detailed information of TA system TA029972

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1869004..1869780
• Replicon: chromosome
• Accession: NC_022226
• Organism: Staphylococcus aureus subsp. aureus CN1

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: SAKOR_RS09190
• Protein ID: WP_000031108.1
• Coordinates: 1869004..1869156 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: SAKOR_RS09195
• Protein ID: WP_001251229.1
• Coordinates: 1869181..1869780 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAKOR_RS09170	1864920..1865741	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
SAKOR_RS09175	1866194..1867579	-	1386	WP_000116231.1	class II fumarate hydratase	-
SAKOR_RS09180	1867775..1868170	-	396	WP_000901023.1	hypothetical protein	-
SAKOR_RS09190	1869004..1869156	-	153	WP_000031108.1	hypothetical protein	Toxin
SAKOR_RS09195	1869181..1869780	-	600	WP_001251229.1	glucosamine-6-phosphate isomerase	Antitoxin
SAKOR_RS09200	1869938..1870408	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
SAKOR_RS09205	1870413..1871540	-	1128	WP_029160281.1	tRNA epoxyqueuosine(34) reductase QueG	-
SAKOR_RS09210	1871691..1872413	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
SAKOR_RS09215	1872406..1873863	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T29972 WP_000031108.1 NC_022226:c1869156-1869004 [Staphylococcus aureus subsp. aureus CN1]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T29972 NC_022226:c1869156-1869004 [Staphylococcus aureus subsp. aureus CN1]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22329.45 Da
• Isoelectric Point: 5.1445

>AT29972 WP_001251229.1 NC_022226:c1869780-1869181 [Staphylococcus aureus subsp. aureus CN1]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEGLGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT29972 NC_022226:c1869780-1869181 [Staphylococcus aureus subsp. aureus CN1]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGGGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: X5E2E6