29969

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 831300..831777 Replicon chromosome
Accession NC_022226
Organism Staphylococcus aureus subsp. aureus CN1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAKOR_RS04030 Protein ID WP_000052076.1
Coordinates 831300..831488 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAKOR_RS04035 Protein ID WP_001059690.1
Coordinates 831517..831777 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAKOR_RS04000 827290..827811 + 522 WP_000824484.1 hypothetical protein -
SAKOR_RS04005 828152..828838 + 687 WP_001792695.1 thermonuclease family protein -
SAKOR_RS04010 829195..829395 + 201 WP_001059082.1 cold-shock protein -
SAKOR_RS04015 829891..830109 - 219 WP_000005886.1 hypothetical protein -
SAKOR_RS04020 830171..830455 - 285 WP_001004395.1 hypothetical protein -
SAKOR_RS04025 830543..831112 - 570 WP_001106654.1 hypothetical protein -
SAKOR_RS04030 831300..831488 - 189 WP_000052076.1 hypothetical protein Toxin
SAKOR_RS04035 831517..831777 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAKOR_RS04040 832118..832321 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAKOR_RS04045 832318..832554 - 237 WP_000368687.1 hypothetical protein -
SAKOR_RS04050 832779..833360 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAKOR_RS04055 833433..834050 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAKOR_RS04060 834205..834699 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAKOR_RS04065 835098..835520 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAKOR_RS04070 835668..836384 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T29969 WP_000052076.1 NC_022226:c831488-831300 [Staphylococcus aureus subsp. aureus CN1]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T29969 NC_022226:c831488-831300 [Staphylococcus aureus subsp. aureus CN1]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT29969 WP_001059690.1 NC_022226:c831777-831517 [Staphylococcus aureus subsp. aureus CN1]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT29969 NC_022226:c831777-831517 [Staphylococcus aureus subsp. aureus CN1]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References