Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 54842..55452 Replicon plasmid unnamed
Accession NC_022225
Organism Listonella anguillarum M3

Toxin (Protein)


Gene name PumA Uniprot ID A0A3M7LLW0
Locus tag N175_RS18510 Protein ID WP_038529385.1
Coordinates 54842..55138 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID Q6W4R6
Locus tag N175_RS18515 Protein ID WP_011154656.1
Coordinates 55162..55452 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N175_RS18490 50101..51015 - 915 WP_011154651.1 helicase RepA family protein -
N175_RS18495 51012..52037 - 1026 WP_020977927.1 hypothetical protein -
N175_RS18500 52957..54204 - 1248 WP_013856937.1 IS91-like element ISVa3 family transposase -
N175_RS18505 54483..54701 + 219 WP_107489848.1 hypothetical protein -
N175_RS18510 54842..55138 + 297 WP_038529385.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N175_RS18515 55162..55452 + 291 WP_011154656.1 putative addiction module antidote protein Antitoxin
N175_RS18655 55581..56795 - 1215 WP_020977929.1 hypothetical protein -
N175_RS18530 56797..57180 - 384 WP_011154658.1 hypothetical protein -
N175_RS18535 57186..58157 - 972 WP_011154659.1 ParB/RepB/Spo0J family partition protein -
N175_RS18540 58154..58948 - 795 WP_020977930.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - bauB 1..66164 66164


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-90)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11097.89 Da        Isoelectric Point: 10.7080

>T29968 WP_038529385.1 NC_022225:54842-55138 [Vibrio anguillarum M3]
MFTIKRTQLFDDWLKTLKDAQARGAITARVQRLTQGLSGDVKPVGSGISELRIHVGKGYRVYFKRSGKQIVVLLCGGNKK
TQNQDIERAKELVQYFDL

Download         Length: 297 bp

>T29968 NC_022225:54842-55138 [Vibrio anguillarum M3]
ATGTTCACTATAAAGCGCACGCAACTTTTTGATGATTGGTTGAAGACACTTAAAGATGCTCAGGCACGAGGTGCTATCAC
TGCTCGTGTTCAGCGCCTTACTCAGGGTTTGAGTGGGGATGTTAAGCCGGTTGGTTCGGGCATTAGTGAGCTTAGGATAC
ATGTCGGTAAAGGTTATCGAGTTTATTTTAAGCGTAGTGGAAAACAGATCGTTGTCTTACTTTGCGGTGGCAATAAGAAA
ACTCAGAATCAAGATATCGAACGCGCTAAAGAGTTGGTTCAATATTTTGATTTGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10273.59 Da        Isoelectric Point: 4.3148

>AT29968 WP_011154656.1 NC_022225:55162-55452 [Vibrio anguillarum M3]
MNITRLDDFDPADYLDNAESIQAYIDEAVATGDAAFISQSLGVIARAKGMNTLAEETGLSRETLYRTLSVKGNPNLKTLI
SITNALGVSVKLGSYC

Download         Length: 291 bp

>AT29968 NC_022225:55162-55452 [Vibrio anguillarum M3]
ATGAATATTACCAGGCTCGATGATTTTGATCCTGCTGACTATCTTGATAATGCTGAATCTATACAGGCATATATTGATGA
GGCGGTAGCAACTGGTGATGCTGCTTTTATTAGTCAATCCTTGGGTGTTATAGCCCGTGCCAAAGGTATGAATACGCTAG
CAGAGGAAACCGGTTTATCTCGTGAAACTTTATATAGAACATTAAGCGTTAAAGGGAATCCTAACCTTAAAACGCTTATC
TCTATCACTAATGCGCTTGGTGTATCTGTCAAACTCGGCTCTTACTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M7LLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A3M7LK76

References