Detailed information of TA system TA029966

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 943474..944002
• Replicon: chromosome
• Accession: NC_022224
• Organism: Listonella anguillarum M3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F7YRA6
• Locus tag: N175_RS18045
• Protein ID: WP_013868556.1
• Coordinates: 943715..944002 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F7YRA5
• Locus tag: N175_RS18040
• Protein ID: WP_013868555.1
• Coordinates: 943474..943725 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N175_RS19630	938704..938979	+	276	WP_013868550.1	hypothetical protein	-
N175_RS18020	939338..940881	-	1544	Protein_808	IS66 family transposase	-
N175_RS19445	940941..941114	-	174	Protein_809	IS66 family insertion sequence element accessory protein TnpB	-
N175_RS19090	941293..941611	-	319	Protein_810	IS66 family insertion sequence element accessory protein TnpB	-
N175_RS18030	941695..942528	-	834	Protein_811	IS30-like element ISVa6 family transposase	-
N175_RS18035	942775..943260	+	486	WP_107489895.1	hypothetical protein	-
N175_RS18040	943474..943725	+	252	WP_013868555.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
N175_RS18045	943715..944002	+	288	WP_013868556.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
N175_RS19100	944669..944842	-	174	Protein_815	pentapeptide repeat-containing protein	-
N175_RS18050	945737..946393	-	657	WP_013868559.1	hypothetical protein	-
N175_RS19110	946433..946549	-	117	WP_080749045.1	DUF3265 domain-containing protein	-
N175_RS18055	946546..946890	-	345	WP_013868560.1	hypothetical protein	-
N175_RS18060	947041..947589	-	549	WP_019281391.1	hypothetical protein	-
N175_RS19115	947643..947768	-	126	WP_013868562.1	DUF3265 domain-containing protein	-
N175_RS18065	948276..948557	-	282	WP_029190024.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	934165..944842	10677
	-	inside	Integron	-	-	945053..951388	6335

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-70)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11064.07 Da
• Isoelectric Point: 10.5506

>T29966 WP_013868556.1 NC_022224:943715-944002 [Vibrio anguillarum M3]
MTYKLKFLPAAKKEWSKLAPPIQSQFKKKLKERLENPHVPSSKLRGYDSVYKIKLRTAGYRLAYEVIDDEIVVYVLAIGK
RDKDAVYKKLASRFS

Nucleotide

• Length: 288 bp

>T29966 NC_022224:943715-944002 [Vibrio anguillarum M3]
ATGACTTATAAGCTAAAATTTCTACCGGCTGCCAAGAAAGAGTGGAGTAAGTTAGCTCCACCAATTCAAAGTCAGTTCAA
AAAGAAGCTTAAAGAGCGTCTGGAAAACCCGCATGTTCCTTCTTCTAAACTGCGTGGCTATGACTCAGTTTATAAGATCA
AACTACGTACAGCAGGCTATCGCTTAGCCTATGAAGTCATTGATGATGAAATCGTGGTGTACGTGTTAGCTATTGGAAAA
CGAGATAAAGATGCAGTGTACAAAAAGTTAGCATCAAGGTTCTCGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9154.36 Da
• Isoelectric Point: 4.0414

>AT29966 WP_013868555.1 NC_022224:943474-943725 [Vibrio anguillarum M3]
MRQVLADCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEFLMDMLDDYELAKLVESRRGELSEAVEVNI
DDL

Nucleotide

• Length: 252 bp

>AT29966 NC_022224:943474-943725 [Vibrio anguillarum M3]
ATGAGACAGGTTTTAGCTGATTGTTCTGCAAGTATTTCTGAGTTAAAGAAAAATCCAACCGCTTTACTAAACGAAGCTGA
TGGTTCTGCCATTGCTATTCTAAACCACAATAAGCCAGCAGCTTATCTTGTCCCAGCAGAAACTTATGAGTTTCTAATGG
ATATGCTCGATGACTATGAGCTTGCTAAACTAGTTGAAAGTCGCCGTGGTGAATTGTCTGAAGCGGTGGAAGTAAATATC
GATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A1E5BHG0

Antitoxin

• AlphaFold DB: A0A7X8TZB8