Detailed information of TA system TA029956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1985845..1986377
• Replicon: chromosome
• Accession: NC_022222
• Organism: Staphylococcus aureus subsp. aureus 6850

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q8VLW9
• Locus tag: RSAU_RS09910
• Protein ID: WP_001103944.1
• Coordinates: 1985845..1986165 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: RSAU_RS09915
• Protein ID: WP_001058486.1
• Coordinates: 1986168..1986377 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RSAU_RS09890	1981847..1982488	-	642	WP_020977425.1	mobile element-associated protein	-
RSAU_RS09895	1982485..1982865	-	381	WP_020977426.1	hypothetical protein	-
RSAU_RS09900	1983195..1984895	-	1701	WP_000447470.1	DUF927 domain-containing protein	-
RSAU_RS09905	1984909..1985778	-	870	WP_001002689.1	primase alpha helix C-terminal domain-containing protein	-
RSAU_RS09910	1985845..1986165	-	321	WP_001103944.1	DUF1474 family protein	Toxin
RSAU_RS09915	1986168..1986377	-	210	WP_001058486.1	hypothetical protein	Antitoxin
RSAU_RS09920	1986370..1986516	-	147	WP_000708434.1	hypothetical protein	-
RSAU_RS09925	1986513..1986830	-	318	WP_020977427.1	helix-turn-helix domain-containing protein	-
RSAU_RS09930	1986835..1987053	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
RSAU_RS09935	1987226..1987900	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
RSAU_RS09940	1987914..1989086	+	1173	WP_000179346.1	site-specific integrase	-
RSAU_RS09945	1989155..1990771	-	1617	WP_020977428.1	chaperonin GroEL	-
RSAU_RS09950	1990847..1991131	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	1967037..1994105	27068

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.31 Da
• Isoelectric Point: 4.8519

>T29956 WP_001103944.1 NC_022222:c1986165-1985845 [Staphylococcus aureus subsp. aureus 6850]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKKLKITE

Nucleotide

• Length: 321 bp

>T29956 NC_022222:c1986165-1985845 [Staphylococcus aureus subsp. aureus 6850]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT29956 WP_001058486.1 NC_022222:c1986377-1986168 [Staphylococcus aureus subsp. aureus 6850]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT29956 NC_022222:c1986377-1986168 [Staphylococcus aureus subsp. aureus 6850]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q8VLW9