Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1858802..1859578 Replicon chromosome
Accession NC_022222
Organism Staphylococcus aureus subsp. aureus 6850

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag RSAU_RS09150 Protein ID WP_000031108.1
Coordinates 1858802..1858954 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag RSAU_RS09155 Protein ID WP_001251219.1
Coordinates 1858979..1859578 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RSAU_RS09125 1854882..1855703 + 822 WP_020977385.1 RluA family pseudouridine synthase -
RSAU_RS09130 1856167..1857552 - 1386 WP_020977386.1 class II fumarate hydratase -
RSAU_RS09135 1857748..1858143 - 396 WP_000901023.1 hypothetical protein -
RSAU_RS09150 1858802..1858954 - 153 WP_000031108.1 hypothetical protein Toxin
RSAU_RS09155 1858979..1859578 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
RSAU_RS09160 1859738..1860208 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
RSAU_RS09165 1860213..1861340 - 1128 WP_020977387.1 tRNA epoxyqueuosine(34) reductase QueG -
RSAU_RS09170 1861491..1862213 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
RSAU_RS09175 1862206..1863663 - 1458 WP_020977388.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T29955 WP_000031108.1 NC_022222:c1858954-1858802 [Staphylococcus aureus subsp. aureus 6850]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T29955 NC_022222:c1858954-1858802 [Staphylococcus aureus subsp. aureus 6850]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT29955 WP_001251219.1 NC_022222:c1859578-1858979 [Staphylococcus aureus subsp. aureus 6850]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT29955 NC_022222:c1859578-1858979 [Staphylococcus aureus subsp. aureus 6850]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTTGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References