Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 838855..839332 Replicon chromosome
Accession NC_022222
Organism Staphylococcus aureus subsp. aureus 6850

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RSAU_RS04035 Protein ID WP_000052076.1
Coordinates 838855..839043 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RSAU_RS04040 Protein ID WP_001059690.1
Coordinates 839072..839332 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RSAU_RS04005 834891..835363 + 473 Protein_759 hypothetical protein -
RSAU_RS04010 835704..836390 + 687 WP_001641381.1 thermonuclease family protein -
RSAU_RS04015 836747..836947 + 201 WP_001059082.1 cold-shock protein -
RSAU_RS04020 837445..837663 - 219 WP_000005880.1 hypothetical protein -
RSAU_RS04025 837726..838010 - 285 WP_001004401.1 hypothetical protein -
RSAU_RS04030 838098..838667 - 570 WP_020977093.1 hypothetical protein -
RSAU_RS04035 838855..839043 - 189 WP_000052076.1 hypothetical protein Toxin
RSAU_RS04040 839072..839332 - 261 WP_001059690.1 hypothetical protein Antitoxin
RSAU_RS04045 839672..839875 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RSAU_RS04050 839872..840108 - 237 WP_000368687.1 hypothetical protein -
RSAU_RS04055 840333..840914 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
RSAU_RS04060 840987..841604 - 618 WP_020977094.1 LysE/ArgO family amino acid transporter -
RSAU_RS04065 841897..842391 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
RSAU_RS04070 842790..843212 - 423 WP_020977095.1 organic hydroperoxide resistance protein -
RSAU_RS04075 843360..844076 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T29952 WP_000052076.1 NC_022222:c839043-838855 [Staphylococcus aureus subsp. aureus 6850]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T29952 NC_022222:c839043-838855 [Staphylococcus aureus subsp. aureus 6850]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT29952 WP_001059690.1 NC_022222:c839332-839072 [Staphylococcus aureus subsp. aureus 6850]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT29952 NC_022222:c839332-839072 [Staphylococcus aureus subsp. aureus 6850]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References