Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 2226023..2226530 Replicon chromosome
Accession NC_022196
Organism Fusobacterium nucleatum subsp. vincentii 3 1 36A2

Toxin (Protein)


Gene name yoeB Uniprot ID C7XST6
Locus tag HMPREF0946_RS10665 Protein ID WP_020789278.1
Coordinates 2226023..2226283 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID U7TRN8
Locus tag HMPREF0946_RS10670 Protein ID WP_005892688.1
Coordinates 2226276..2226530 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0946_RS10640 2221588..2222865 - 1278 WP_008800438.1 D-alanyl-D-alanine carboxypeptidase -
HMPREF0946_RS10645 2222949..2223335 - 387 WP_008796539.1 Fe-S cluster assembly scaffold protein NifU -
HMPREF0946_RS10650 2223408..2224604 - 1197 WP_008796538.1 cysteine desulfurase NifS -
HMPREF0946_RS10655 2224683..2225333 - 651 WP_008800437.1 endonuclease III -
HMPREF0946_RS10660 2225524..2226006 - 483 WP_008800436.1 GNAT family N-acetyltransferase -
HMPREF0946_RS10665 2226023..2226283 - 261 WP_020789278.1 Txe/YoeB family addiction module toxin Toxin
HMPREF0946_RS10670 2226276..2226530 - 255 WP_005892688.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HMPREF0946_RS10675 2226658..2227866 - 1209 WP_020789277.1 tyrosine--tRNA ligase -
HMPREF0946_RS10680 2228100..2229374 - 1275 WP_008800433.1 branched-chain amino acid transport system II carrier protein -
HMPREF0946_RS10685 2229522..2229884 - 363 WP_008796531.1 arsenate reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10275.79 Da        Isoelectric Point: 9.3654

>T29939 WP_020789278.1 NC_022196:c2226283-2226023 [Fusobacterium nucleatum subsp. vincentii 3_1_36A2]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGALNGIGKPEVLKNENAYSRRIDEKNRLVYRIVDGVIWIIAC
KGHYEE

Download         Length: 261 bp

>T29939 NC_022196:c2226283-2226023 [Fusobacterium nucleatum subsp. vincentii 3_1_36A2]
ATGAATAATTTAGTATGGACACATAAAGCTTGGCAAGATTATCTATATTGGCAAACTCAGGATAAAAAAACTTTAAAAAA
GATAAATGAATTAGTCAAAGATATTGAAAGAAATGGAGCTTTAAATGGGATAGGCAAGCCAGAAGTATTAAAAAATGAAA
ATGCATATAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTGTAGATGGGGTTATATGGATAATTGCTTGT
AAAGGTCATTATGAGGAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9824.17 Da        Isoelectric Point: 4.4453

>AT29939 WP_005892688.1 NC_022196:c2226530-2226276 [Fusobacterium nucleatum subsp. vincentii 3_1_36A2]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Download         Length: 255 bp

>AT29939 NC_022196:c2226530-2226276 [Fusobacterium nucleatum subsp. vincentii 3_1_36A2]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTAGATAATGATGAAGATAT
TATTATAACAAGAAAAAATGAAAGAAATGTTGTTCTATTAAGTCTTGATAAATATAATGAGTTTTTAAAAGCTATGAGAA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAGGCAGGAAAAGGAGAAATCCATGATTTAATAGAG
GTTGATGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E9ETF6

Antitoxin

Source ID Structure
AlphaFold DB A0A806UAF3

References