Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2101682..2102196 Replicon chromosome
Accession NC_022113
Organism Staphylococcus aureus subsp. aureus 55/2053

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag SAAG_RS10555 Protein ID WP_000581791.1
Coordinates 2101682..2101891 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag SAAG_RS10560 Protein ID WP_000138934.1
Coordinates 2101903..2102196 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAAG_RS10530 2097188..2098258 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
SAAG_RS10535 2098576..2099778 + 1203 WP_001109940.1 rod shape-determining protein RodA -
SAAG_RS10540 2099939..2100148 - 210 Protein_2008 transposase -
SAAG_RS10545 2100202..2101005 - 804 Protein_2009 IS1182-like element ISSau3 family transposase -
SAAG_RS10550 2101417..2101554 - 138 WP_000828354.1 hypothetical protein -
SAAG_RS10555 2101682..2101891 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
SAAG_RS10560 2101903..2102196 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAAG_RS10565 2102362..2103846 + 1485 WP_000571560.1 cardiolipin synthase -
SAAG_RS10570 2103874..2104521 + 648 WP_001187612.1 HD domain-containing protein -
SAAG_RS10580 2105136..2106008 - 873 WP_000725802.1 membrane protein insertase YidC -
SAAG_RS10585 2106094..2106735 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T29931 WP_000581791.1 NC_022113:c2101891-2101682 [Staphylococcus aureus subsp. aureus 55/2053]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T29931 NC_022113:c2101891-2101682 [Staphylococcus aureus subsp. aureus 55/2053]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT29931 WP_000138934.1 NC_022113:c2102196-2101903 [Staphylococcus aureus subsp. aureus 55/2053]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT29931 NC_022113:c2102196-2101903 [Staphylococcus aureus subsp. aureus 55/2053]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References