Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 766289..766766 Replicon chromosome
Accession NC_022113
Organism Staphylococcus aureus subsp. aureus 55/2053

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAAG_RS03575 Protein ID WP_000052076.1
Coordinates 766289..766477 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAAG_RS03580 Protein ID WP_001059690.1
Coordinates 766506..766766 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAAG_RS03545 762242..762799 + 558 WP_000824491.1 hypothetical protein -
SAAG_RS03550 763140..763826 + 687 WP_001574556.1 thermonuclease family protein -
SAAG_RS03555 764183..764383 + 201 WP_001059082.1 cold-shock protein -
SAAG_RS03560 764880..765098 - 219 WP_000005879.1 hypothetical protein -
SAAG_RS03565 765160..765444 - 285 WP_001004401.1 hypothetical protein -
SAAG_RS03570 765532..766101 - 570 WP_001106663.1 hypothetical protein -
SAAG_RS03575 766289..766477 - 189 WP_000052076.1 hypothetical protein Toxin
SAAG_RS03580 766506..766766 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAAG_RS03585 767107..767310 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAAG_RS03590 767307..767543 - 237 WP_000368687.1 hypothetical protein -
SAAG_RS03595 767768..768349 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SAAG_RS03600 768422..769039 - 618 WP_000255542.1 LysE/ArgO family amino acid transporter -
SAAG_RS03605 769195..769689 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAAG_RS03610 770088..770510 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SAAG_RS03615 770658..771374 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T29923 WP_000052076.1 NC_022113:c766477-766289 [Staphylococcus aureus subsp. aureus 55/2053]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T29923 NC_022113:c766477-766289 [Staphylococcus aureus subsp. aureus 55/2053]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT29923 WP_001059690.1 NC_022113:c766766-766506 [Staphylococcus aureus subsp. aureus 55/2053]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT29923 NC_022113:c766766-766506 [Staphylococcus aureus subsp. aureus 55/2053]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References