Detailed information of TA system TA029920

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 952820..953349
• Replicon: chromosome
• Accession: NC_022097
• Organism: Treponema pedis str. T A4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: TPE_RS04100
• Protein ID: WP_038096190.1
• Coordinates: 953095..953349 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S5ZYZ1
• Locus tag: TPE_RS04095
• Protein ID: WP_020964673.1
• Coordinates: 952820..953095 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TPE_RS04070	948842..949189	+	348	WP_024466099.1	HNH endonuclease	-
TPE_RS14180	949372..949548	+	177	WP_187289356.1	hypothetical protein	-
TPE_RS04075	949550..949915	+	366	WP_029408977.1	hypothetical protein	-
TPE_RS04080	950563..951852	+	1290	WP_020964670.1	ATP-binding protein	-
TPE_RS04085	951879..952163	+	285	WP_020964671.1	hypothetical protein	-
TPE_RS04090	952216..952464	+	249	WP_020964672.1	hypothetical protein	-
TPE_RS04095	952820..953095	+	276	WP_020964673.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
TPE_RS04100	953095..953349	+	255	WP_038096190.1	type II toxin-antitoxin system YafQ family toxin	Toxin
TPE_RS04105	953460..953813	+	354	Protein_804	HEAT repeat domain-containing protein	-
TPE_RS04110	953797..954261	+	465	WP_020964676.1	hypothetical protein	-
TPE_RS04115	954595..956316	+	1722	WP_020964677.1	ABC transporter ATP-binding protein/permease	-
TPE_RS04120	956404..956859	-	456	WP_020964678.1	helix-turn-helix transcriptional regulator	-
TPE_RS14185	957051..957191	+	141	WP_187289357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-76)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9964.74 Da
• Isoelectric Point: 9.9845

>T29920 WP_038096190.1 NC_022097:953095-953349 [Treponema pedis str. T A4]
MSYKLKKTHQFKASYKLAKKRGLDVSLLEDIVEKLRTDKPLEAKYRNHELAGKFKGVWECHIQPDWLLLYYKDKNILVLT
LVDT

Nucleotide

• Length: 255 bp

>T29920 NC_022097:953095-953349 [Treponema pedis str. T A4]
ATGTCTTATAAATTGAAAAAGACTCATCAGTTCAAAGCAAGTTACAAATTAGCAAAAAAACGAGGATTGGATGTATCTCT
TTTAGAAGATATAGTTGAGAAATTACGGACGGACAAACCATTAGAAGCAAAATATCGAAATCATGAACTTGCCGGAAAGT
TCAAAGGAGTTTGGGAATGTCATATTCAACCGGATTGGCTTTTACTATATTACAAAGATAAAAATATCCTTGTTTTAACC
TTGGTTGATACCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10232.64 Da
• Isoelectric Point: 4.3575

>AT29920 WP_020964673.1 NC_022097:952820-953095 [Treponema pedis str. T A4]
MATVILQTRVDVETKKEAESLFTSLGLDITTAIRLFLKQAINQQKIPFDIVPPQEIFSEYTLSAIEEAKKISSDSSVKSY
SSARELFEDCE

Nucleotide

• Length: 276 bp

>AT29920 NC_022097:952820-953095 [Treponema pedis str. T A4]
ATGGCAACAGTAATTTTACAAACGCGAGTTGATGTGGAAACAAAAAAAGAAGCCGAATCTCTTTTTACTTCACTGGGATT
GGATATAACAACGGCAATTCGTCTATTTCTTAAACAAGCCATCAATCAACAAAAGATTCCTTTTGATATTGTTCCGCCGC
AAGAGATTTTTTCAGAATATACATTATCTGCAATTGAAGAAGCCAAAAAAATTAGCAGTGATTCAAGTGTAAAATCATAT
TCTTCAGCAAGGGAACTCTTTGAGGATTGTGAATAA

Structures

Antitoxin

• AlphaFold DB: S5ZYZ1