Detailed information of TA system TA029919

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1663296..1663933
• Replicon: chromosome
• Accession: NC_022093
• Organism: Thermofilum sp. 1910b

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: S5ZA02
• Locus tag: N186_RS08970
• Protein ID: WP_020963502.1
• Coordinates: 1663520..1663933 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: S5ZXS8
• Locus tag: N186_RS08965
• Protein ID: WP_020963501.1
• Coordinates: 1663296..1663520 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N186_RS09800 (N186_09260)	1659002..1659178	+	177	WP_020963495.1	hypothetical protein	-
N186_RS08940 (N186_09265)	1659520..1659699	+	180	WP_240366737.1	hypothetical protein	-
N186_RS08945 (N186_09270)	1659702..1660103	+	402	WP_020963497.1	type II toxin-antitoxin system VapC family toxin	-
N186_RS08950 (N186_09275)	1660207..1660536	-	330	WP_020963498.1	anion permease	-
N186_RS08955 (N186_09280)	1660695..1661987	-	1293	WP_148682197.1	hypothetical protein	-
N186_RS08960 (N186_09285)	1662031..1662906	-	876	WP_020963500.1	ATP-dependent Clp protease proteolytic subunit	-
N186_RS08965 (N186_09290)	1663296..1663520	+	225	WP_020963501.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
N186_RS08970 (N186_09295)	1663520..1663933	+	414	WP_020963502.1	type II toxin-antitoxin system VapC family toxin	Toxin
N186_RS08975 (N186_09300)	1664188..1664544	-	357	WP_020963503.1	nucleotidyltransferase domain-containing protein	-
N186_RS08980 (N186_09305)	1664929..1665741	+	813	WP_020963504.1	putative CRISPR-associated protein	-
N186_RS08985 (N186_09310)	1665812..1666039	+	228	WP_052885714.1	DUF167 domain-containing protein	-
N186_RS08990 (N186_09315)	1666382..1667344	-	963	WP_052885715.1	ABC transporter ATP-binding protein	-
N186_RS08995 (N186_09320)	1667350..1668351	-	1002	WP_020963507.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (6-126)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15835.50 Da
• Isoelectric Point: 4.8858

>T29919 WP_020963502.1 NC_022093:1663520-1663933 [Thermofilum adornatum]
MVEYLLDASALYPLMLKMKDKLFDYLNLFVVLDLTVYEIGNVIWKESRVGRVRAPKALAIAFAEVFREVKVVRLRDEETA
DVLELALAEEITFYDAAYLYAARKLRLRLVTEDSDLKKYPESVGLEELVAGLERSRR

Nucleotide

• Length: 414 bp

>T29919 NC_022093:1663520-1663933 [Thermofilum adornatum]
ATGGTTGAGTACCTGCTTGACGCCTCTGCACTTTATCCACTCATGTTGAAGATGAAGGATAAGCTTTTCGACTACTTAAA
TCTCTTTGTAGTGCTGGATCTGACAGTATATGAGATTGGCAACGTGATTTGGAAGGAGAGTCGGGTAGGCAGGGTTAGGG
CTCCTAAGGCTTTAGCGATAGCATTCGCAGAGGTATTTAGGGAAGTTAAGGTTGTCAGATTGAGGGACGAGGAAACAGCG
GACGTCTTAGAGCTGGCTTTGGCGGAGGAAATAACCTTCTATGATGCGGCTTACCTGTACGCAGCTAGAAAGCTCCGCTT
AAGGCTTGTGACCGAGGACTCGGATTTGAAAAAGTACCCAGAATCTGTAGGCTTAGAAGAGCTCGTTGCAGGGCTAGAGC
GTTCGAGGCGTTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8773.12 Da
• Isoelectric Point: 6.9899

>AT29919 WP_020963501.1 NC_022093:1663296-1663520 [Thermofilum adornatum]
VSTEVLSVRVRRELKEEALRLGIDVRSVIERALEEEVRKAKKEKFRELLEEALKGCDITVEEWVRAVKETRREH

Nucleotide

• Length: 225 bp

>AT29919 NC_022093:1663296-1663520 [Thermofilum adornatum]
GTGTCTACTGAAGTGCTATCTGTTAGGGTCAGGAGAGAGCTTAAGGAGGAAGCTTTGAGGCTGGGAATCGATGTTAGGAG
TGTTATTGAGAGGGCTCTCGAGGAGGAGGTAAGAAAGGCGAAGAAGGAGAAGTTCAGGGAGTTGCTCGAGGAAGCCCTAA
AGGGTTGCGACATAACGGTTGAAGAATGGGTTAGGGCAGTAAAGGAAACTAGGAGGGAACATTAA

Structures

Toxin

• AlphaFold DB: S5ZA02

Antitoxin

• AlphaFold DB: S5ZXS8