Detailed information of TA system TA029917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 1459512..1460137
• Replicon: chromosome
• Accession: NC_022084
• Organism: Thermococcus litoralis DSM 5473

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H3ZQA2
• Locus tag: OCC_RS07930
• Protein ID: WP_004069570.1
• Coordinates: 1459727..1460137 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: H3ZQA1
• Locus tag: OCC_RS07925
• Protein ID: WP_004069568.1
• Coordinates: 1459512..1459739 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCC_RS07905 (OCC_03377)	1454679..1455134	+	456	WP_202950627.1	OsmC family protein	-
OCC_RS07910 (OCC_03382)	1455131..1456432	-	1302	WP_004069562.1	acetamidase/formamidase family protein	-
OCC_RS07915 (OCC_03387)	1456596..1457777	+	1182	WP_004069564.1	CGP-CTERM-anchored Cys-rich protein	-
OCC_RS07920 (OCC_03392)	1458103..1459434	+	1332	WP_004069566.1	TrpB-like pyridoxal phosphate-dependent enzyme	-
OCC_RS07925 (OCC_03397)	1459512..1459739	+	228	WP_004069568.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
OCC_RS07930 (OCC_03402)	1459727..1460137	+	411	WP_004069570.1	PIN domain-containing protein	Toxin
OCC_RS07935 (OCC_03407)	1460179..1460811	-	633	WP_004069572.1	MBL fold metallo-hydrolase	-
OCC_RS07940 (OCC_03412)	1460948..1461550	+	603	WP_004069580.1	ArsR family transcriptional regulator	-
OCC_RS07945 (OCC_03417)	1461547..1461750	-	204	WP_004069582.1	30S ribosomal protein S17e	-
OCC_RS07955 (OCC_03422)	1462266..1462682	+	417	WP_004069584.1	DUF371 domain-containing protein	-
OCC_RS07960 (OCC_03427)	1462757..1463878	+	1122	WP_004069586.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (4-43)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15927.50 Da
• Isoelectric Point: 9.2373

>T29917 WP_004069570.1 NC_022084:1459727-1460137 [Thermococcus litoralis DSM 5473]
MSAVIDTNVLIYDTFSDSGFHEKARSLLNSLDKWYVPSIVLQEYVWFFKNQGFSVKEARTMLLEYTSDPRFRSLVDDYKI
ILRALELLEREKLSLSRFNDTVILIHALEKGYLATFDQRLRKLATKLGVKVLPKEF

Nucleotide

• Length: 411 bp

>T29917 NC_022084:1459727-1460137 [Thermococcus litoralis DSM 5473]
ATGTCTGCAGTGATAGATACCAATGTTTTGATTTATGACACCTTTAGCGACTCTGGCTTCCATGAAAAGGCGAGAAGCCT
TCTGAATTCTCTCGATAAATGGTACGTTCCATCGATAGTGCTTCAGGAGTATGTGTGGTTCTTTAAAAACCAAGGGTTTT
CAGTTAAGGAAGCTAGGACGATGCTCTTAGAGTACACCTCTGACCCGAGGTTTAGAAGCCTCGTCGATGATTATAAGATA
ATCCTCCGCGCCCTTGAGCTCCTTGAAAGGGAGAAGCTCTCTCTATCGCGCTTCAATGACACGGTAATTCTCATTCACGC
GCTGGAGAAAGGTTATTTGGCAACTTTTGACCAAAGGCTCAGAAAGCTTGCGACAAAGCTCGGAGTCAAAGTTTTGCCGA
AGGAGTTTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8645.27 Da
• Isoelectric Point: 9.6546

>AT29917 WP_004069568.1 NC_022084:1459512-1459739 [Thermococcus litoralis DSM 5473]
MPLTKVTRNYQITIPAEIRKALGIKEGEVLEVKLEDGRIIIERPKKERKTLKLGKKISPEEIEKSIEEGMKECLQ

Nucleotide

• Length: 228 bp

>AT29917 NC_022084:1459512-1459739 [Thermococcus litoralis DSM 5473]
ATGCCACTCACAAAAGTCACCCGGAACTACCAGATAACGATCCCCGCAGAGATCAGGAAGGCTCTTGGGATTAAGGAAGG
TGAAGTGCTTGAAGTGAAGCTCGAAGACGGGAGGATTATTATAGAACGGCCCAAAAAAGAAAGGAAAACCCTCAAGCTCG
GCAAAAAGATATCTCCTGAGGAAATTGAGAAATCCATAGAAGAGGGGATGAAAGAATGTCTGCAGTGA

Structures

Toxin

• AlphaFold DB: H3ZQA2

Antitoxin

• AlphaFold DB: H3ZQA1