Detailed information of TA system TA029916

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 709372..709972
• Replicon: chromosome
• Accession: NC_022084
• Organism: Thermococcus litoralis DSM 5473

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H3ZNC2
• Locus tag: OCC_RS03970
• Protein ID: WP_004068188.1
• Coordinates: 709580..709972 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: H3ZNC1
• Locus tag: OCC_RS03965
• Protein ID: WP_004068187.1
• Coordinates: 709372..709593 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCC_RS03935 (OCC_11372)	704537..704728	-	192	WP_004068181.1	hypothetical protein	-
OCC_RS12400	704746..704976	-	231	WP_148290401.1	hypothetical protein	-
OCC_RS03945 (OCC_11382)	705119..705337	-	219	WP_004068183.1	hypothetical protein	-
OCC_RS03950 (OCC_11387)	705658..706479	+	822	WP_004068184.1	class I SAM-dependent methyltransferase	-
OCC_RS03955 (OCC_11392)	706504..707871	+	1368	WP_004068185.1	ATP-binding protein	-
OCC_RS03960 (OCC_11397)	707872..709215	-	1344	WP_084684304.1	M20/M25/M40 family metallo-hydrolase	-
OCC_RS03965 (OCC_11402)	709372..709593	+	222	WP_004068187.1	hypothetical protein	Antitoxin
OCC_RS03970 (OCC_11407)	709580..709972	+	393	WP_004068188.1	type II toxin-antitoxin system VapC family toxin	Toxin
OCC_RS03975 (OCC_11412)	710015..710269	+	255	WP_004068189.1	hypothetical protein	-
OCC_RS03980 (OCC_11417)	710270..711700	-	1431	WP_171814850.1	cysteine--tRNA ligase	-
OCC_RS03985 (OCC_11422)	711823..712737	+	915	WP_004068191.1	peptidylprolyl isomerase	-
OCC_RS03990 (OCC_11427)	712827..713744	+	918	WP_148290402.1	hypothetical protein	-
OCC_RS03995 (OCC_11432)	713754..714347	+	594	WP_004068193.1	CPBP family archaeomyxosortase MrtA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-120)

Antitoxin

• Putative antitoxin VapB3-like (1-73)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14853.24 Da
• Isoelectric Point: 4.7148

>T29916 WP_004068188.1 NC_022084:709580-709972 [Thermococcus litoralis DSM 5473]
VIVIDASALAKVILQEENWDSVPLTEKTATLDYALVEALNAIWKAVIQKRLDEEDAKDRTEALKYLAKSLLLFEAKNYFE
RALEIALKEKITVYDALYIALAEELKADLYTSDVKQFEAAKKYVRVKLIQ

Nucleotide

• Length: 393 bp

>T29916 NC_022084:709580-709972 [Thermococcus litoralis DSM 5473]
GTGATAGTAATTGATGCCTCTGCTCTCGCTAAAGTGATCCTTCAAGAAGAGAACTGGGATAGTGTTCCACTAACGGAAAA
AACTGCAACGCTGGATTACGCTCTTGTTGAGGCACTAAACGCTATTTGGAAGGCTGTTATCCAAAAACGGCTAGATGAAG
AAGACGCAAAAGACAGAACTGAAGCACTGAAGTATCTCGCCAAAAGCCTGTTGCTCTTCGAAGCCAAGAATTACTTTGAG
CGTGCTTTGGAGATAGCGCTGAAGGAAAAAATTACCGTTTACGATGCCCTCTACATAGCCCTTGCGGAAGAACTAAAAGC
TGATCTCTACACCTCTGACGTTAAACAGTTTGAGGCAGCAAAAAAATACGTGAGAGTAAAGCTCATCCAATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8639.00 Da
• Isoelectric Point: 10.6770

>AT29916 WP_004068187.1 NC_022084:709372-709593 [Thermococcus litoralis DSM 5473]
MAVITVRVPDEIKAKMKGININWSEEIRRFIIQRIEEEERKKNLQKALEILKGRKNVEKGFSARSVREDRDSN

Nucleotide

• Length: 222 bp

>AT29916 NC_022084:709372-709593 [Thermococcus litoralis DSM 5473]
ATGGCTGTCATTACAGTTAGGGTTCCAGATGAGATAAAAGCAAAGATGAAGGGAATAAATATAAACTGGAGTGAAGAAAT
AAGGAGGTTCATAATCCAGCGCATAGAAGAGGAAGAAAGGAAGAAAAACCTCCAAAAAGCCCTCGAAATCCTTAAGGGGA
GAAAGAACGTTGAGAAAGGTTTTTCAGCGAGATCTGTGAGGGAGGATCGTGATAGTAATTGA

Structures

Toxin

• AlphaFold DB: H3ZNC2

Antitoxin

• AlphaFold DB: H3ZNC1