Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 214318..214954 Replicon chromosome
Accession NC_022080
Organism Geobacillus sp. JF8

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag M493_RS01190 Protein ID WP_003253417.1
Coordinates 214604..214954 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID S5ZZQ7
Locus tag M493_RS01185 Protein ID WP_020958454.1
Coordinates 214318..214599 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M493_RS01165 210482..211099 - 618 WP_020958449.1 rhomboid family intramembrane serine protease -
M493_RS01170 211253..211642 + 390 WP_020958450.1 holo-ACP synthase -
M493_RS01175 211722..212735 + 1014 WP_020958451.1 outer membrane lipoprotein carrier protein LolA -
M493_RS01180 213036..214190 + 1155 WP_020958452.1 alanine racemase -
M493_RS01185 214318..214599 + 282 WP_020958454.1 hypothetical protein Antitoxin
M493_RS01190 214604..214954 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
M493_RS01195 215555..217717 + 2163 WP_020958455.1 RNA-binding transcriptional accessory protein -
M493_RS18095 217774..217887 - 114 WP_128754812.1 cortex morphogenetic protein CmpA -
M493_RS01200 217979..218440 + 462 WP_020958456.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T29912 WP_003253417.1 NC_022080:214604-214954 [Geobacillus genomosp. 3]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T29912 NC_022080:214604-214954 [Geobacillus genomosp. 3]
TTGATTGTCAAACGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTCGTTGGCTCAGAGCAGGGCGGCGTGCGCCCCGT
GTTGGTGATCCAAAACGATATCGGCAATCGCTTCAGTCCAACGGTTATTGTGGCGGCGATCACGGCGCAAATCCAGAAGG
CGAAGCTGCCGACCCATGTCGAGATCGATGCGAAGCGCTACGGGTTTGAGCGGGACTCGGTCATTTTGCTTGAACAAATC
CGTACGATTGATAAGCAGCGGCTGACTGACAAAATCACCCACCTGGATGATGAGATGATGGACAAAGTCGATGAAGCGCT
GCAAATCAGCTTAGGACTGATCGACTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10641.11 Da        Isoelectric Point: 7.2027

>AT29912 WP_020958454.1 NC_022080:214318-214599 [Geobacillus genomosp. 3]
VSESGATTEIIVRLPQSLLTELDGLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT29912 NC_022080:214318-214599 [Geobacillus genomosp. 3]
GTGTCGGAATCTGGCGCAACAACGGAAATCATCGTTCGTTTGCCGCAGTCGCTGCTGACGGAACTGGACGGGCTTGTGAA
GCAGGAGAACGGCAATCGCAATGAACTCATTTATCAGGCGACGAAAATGTATATTCGTGAGCGGAAAAAACGGCAAATTC
GCGAGGCGATGAGACGAGGCTACATGGAAATGGCCAAAATCAATTTATCTATTGCTTCTGAAGCGTTTCATGCTGAATAT
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A143ML40

References