Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 233408..234062 Replicon plasmid pAMI5
Accession NC_022043
Organism Paracoccus aminophilus JCM 7686

Toxin (Protein)


Gene name vapC Uniprot ID S5Y1B8
Locus tag JCM7686_RS21140 Protein ID WP_020953053.1
Coordinates 233655..234062 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID S5Z1G3
Locus tag JCM7686_RS21135 Protein ID WP_020953052.1
Coordinates 233408..233653 (+) Length 82 a.a.

Genomic Context

JCM7686_RS21120JCM7686_RS21135JCM7686_RS21140JCM7686_RS21155JCM7686_RS21115JCM7686_RS21125JCM7686_RS21130JCM7686_RS21145JCM7686_RS21160
Location: 230089..231045 (957 bp)
Type: Others
Protein ID: WP_020953049.1
Location: 233408..233653 (246 bp)
Type: Antitoxin
Protein ID: WP_020953052.1
Location: 233655..234062 (408 bp)
Type: Toxin
Protein ID: WP_020953053.1
Location: 235990..237162 (1173 bp)
Type: Others
Protein ID: WP_020953055.1
Location: 229054..229914 (861 bp)
Type: Others
Protein ID: WP_041528347.1
Location: 231073..232041 (969 bp)
Type: Others
Protein ID: WP_041528349.1
Location: 232372..233298 (927 bp)
Type: Others
Protein ID: WP_020953051.1
Location: 234308..235546 (1239 bp)
Type: Others
Protein ID: WP_020953054.1
Location: 237256..238827 (1572 bp)
Type: Others
Protein ID: WP_020953056.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JCM7686_RS21115229054..229914-861WP_041528347.1D-amino-acid transaminase-
JCM7686_RS21120230089..231045+957WP_020953049.1LysR family transcriptional regulator-
JCM7686_RS21125231073..232041-969WP_041528349.1YeiH family protein-
JCM7686_RS21130232372..233298-927WP_020953051.1LysR family transcriptional regulator-
JCM7686_RS21135233408..233653+246WP_020953052.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
JCM7686_RS21140233655..234062+408WP_020953053.1type II toxin-antitoxin system VapC family toxinToxin
JCM7686_RS21145234308..235546-1239WP_020953054.1peptidase T-
JCM7686_RS21155235990..237162+1173WP_020953055.1calcium-binding protein-
JCM7686_RS21160237256..238827-1572WP_020953056.1GMC family oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..294017294017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14964.10 Da        Isoelectric Point: 4.6579

>T29908 WP_020953053.1 NC_022043:233655-234062 [Paracoccus aminophilus JCM 7686]
MYLLDTNVISALRRPERAPAVAQWLRGQPDQELYLSVITLGEIERGIARQEIINPGFARDLNDWLDRTTQLFADRILPFG
SVEARIWGRLSATIGHDGADLMIAATALARDAIVVTGNMSDFTPSGCRLLDPFQP

Download         Length: 408 bp

>T29908 NC_022043:233655-234062 [Paracoccus aminophilus JCM 7686]
ATGTATCTCCTTGATACCAATGTGATCTCGGCGCTGCGACGCCCCGAACGGGCGCCCGCGGTCGCGCAATGGCTGCGCGG
CCAGCCGGATCAGGAGCTTTACCTCTCGGTCATCACTCTGGGCGAGATCGAGCGCGGCATTGCTCGGCAAGAGATCATCA
ATCCGGGCTTTGCGCGCGATCTGAACGACTGGCTCGACCGCACGACCCAGCTTTTCGCCGACCGCATCCTGCCCTTCGGC
AGCGTCGAGGCGCGGATCTGGGGCCGGTTGTCCGCGACGATCGGCCATGATGGCGCGGATCTGATGATCGCGGCCACCGC
GCTGGCCCGCGATGCGATCGTTGTCACCGGGAATATGTCCGATTTCACCCCTTCAGGATGCCGCCTGCTCGATCCCTTTC
AGCCCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8914.10 Da        Isoelectric Point: 8.7086

>AT29908 WP_020953052.1 NC_022043:233408-233653 [Paracoccus aminophilus JCM 7686]
MWTLQDAKNRFSAVVDAALSGEPQEVTRRGKPAVVVLSAEDYARMTAAARAARGTFTDHLLGFPGLDLDQRPKARPRDVE
F

Download         Length: 246 bp

>AT29908 NC_022043:233408-233653 [Paracoccus aminophilus JCM 7686]
ATGTGGACTTTGCAAGATGCCAAGAACCGCTTCTCGGCCGTGGTGGATGCCGCGCTGTCGGGCGAGCCGCAAGAGGTCAC
GCGCCGGGGGAAGCCTGCGGTCGTCGTCCTCTCGGCCGAGGATTATGCCCGCATGACCGCCGCTGCCCGGGCGGCGCGCG
GCACCTTCACCGATCACCTCCTTGGTTTTCCGGGCCTCGATCTGGACCAGCGGCCGAAAGCTCGCCCGCGGGATGTCGAG
TTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBS5Y1B8

Antitoxin

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Source
ID
Structure
AlphaFold DBS5Z1G3

References