Detailed information of TA system TA029908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 233408..234062
• Replicon: plasmid pAMI5
• Accession: NC_022043
• Organism: Paracoccus aminophilus JCM 7686

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: S5Y1B8
• Locus tag: JCM7686_RS21140
• Protein ID: WP_020953053.1
• Coordinates: 233655..234062 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: S5Z1G3
• Locus tag: JCM7686_RS21135
• Protein ID: WP_020953052.1
• Coordinates: 233408..233653 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCM7686_RS21115	229054..229914	-	861	WP_041528347.1	D-amino-acid transaminase	-
JCM7686_RS21120	230089..231045	+	957	WP_020953049.1	LysR family transcriptional regulator	-
JCM7686_RS21125	231073..232041	-	969	WP_041528349.1	YeiH family protein	-
JCM7686_RS21130	232372..233298	-	927	WP_020953051.1	LysR family transcriptional regulator	-
JCM7686_RS21135	233408..233653	+	246	WP_020953052.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JCM7686_RS21140	233655..234062	+	408	WP_020953053.1	type II toxin-antitoxin system VapC family toxin	Toxin
JCM7686_RS21145	234308..235546	-	1239	WP_020953054.1	peptidase T	-
JCM7686_RS21155	235990..237162	+	1173	WP_020953055.1	calcium-binding protein	-
JCM7686_RS21160	237256..238827	-	1572	WP_020953056.1	GMC family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..294017	294017

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-117)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-49)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14964.10 Da
• Isoelectric Point: 4.6579

>T29908 WP_020953053.1 NC_022043:233655-234062 [Paracoccus aminophilus JCM 7686]
MYLLDTNVISALRRPERAPAVAQWLRGQPDQELYLSVITLGEIERGIARQEIINPGFARDLNDWLDRTTQLFADRILPFG
SVEARIWGRLSATIGHDGADLMIAATALARDAIVVTGNMSDFTPSGCRLLDPFQP

Nucleotide

• Length: 408 bp

>T29908 NC_022043:233655-234062 [Paracoccus aminophilus JCM 7686]
ATGTATCTCCTTGATACCAATGTGATCTCGGCGCTGCGACGCCCCGAACGGGCGCCCGCGGTCGCGCAATGGCTGCGCGG
CCAGCCGGATCAGGAGCTTTACCTCTCGGTCATCACTCTGGGCGAGATCGAGCGCGGCATTGCTCGGCAAGAGATCATCA
ATCCGGGCTTTGCGCGCGATCTGAACGACTGGCTCGACCGCACGACCCAGCTTTTCGCCGACCGCATCCTGCCCTTCGGC
AGCGTCGAGGCGCGGATCTGGGGCCGGTTGTCCGCGACGATCGGCCATGATGGCGCGGATCTGATGATCGCGGCCACCGC
GCTGGCCCGCGATGCGATCGTTGTCACCGGGAATATGTCCGATTTCACCCCTTCAGGATGCCGCCTGCTCGATCCCTTTC
AGCCCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8914.10 Da
• Isoelectric Point: 8.7086

>AT29908 WP_020953052.1 NC_022043:233408-233653 [Paracoccus aminophilus JCM 7686]
MWTLQDAKNRFSAVVDAALSGEPQEVTRRGKPAVVVLSAEDYARMTAAARAARGTFTDHLLGFPGLDLDQRPKARPRDVE
F

Nucleotide

• Length: 246 bp

>AT29908 NC_022043:233408-233653 [Paracoccus aminophilus JCM 7686]
ATGTGGACTTTGCAAGATGCCAAGAACCGCTTCTCGGCCGTGGTGGATGCCGCGCTGTCGGGCGAGCCGCAAGAGGTCAC
GCGCCGGGGGAAGCCTGCGGTCGTCGTCCTCTCGGCCGAGGATTATGCCCGCATGACCGCCGCTGCCCGGGCGGCGCGCG
GCACCTTCACCGATCACCTCCTTGGTTTTCCGGGCCTCGATCTGGACCAGCGGCCGAAAGCTCGCCCGCGGGATGTCGAG
TTCTGA

Structures

Toxin

• AlphaFold DB: S5Y1B8

Antitoxin

• AlphaFold DB: S5Z1G3