Detailed information of TA system TA029906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 3451271..3451872
• Replicon: chromosome
• Accession: NC_022000
• Organism: Proteus mirabilis BB2000

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: BB2000_RS15350
• Protein ID: WP_020946512.1
• Coordinates: 3451271..3451654 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: BB2000_RS15355
• Protein ID: WP_004246496.1
• Coordinates: 3451651..3451872 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB2000_RS15325	3446644..3447102	+	459	WP_041701462.1	GNAT family N-acetyltransferase	-
BB2000_RS15330	3447198..3447935	-	738	WP_020946509.1	sel1 repeat family protein	-
BB2000_RS15335	3448044..3448943	+	900	WP_020946510.1	N-acetylmuramic acid 6-phosphate etherase	-
BB2000_RS15340	3449300..3450538	-	1239	WP_020946511.1	HipA domain-containing protein	-
BB2000_RS15345	3450551..3450865	-	315	WP_041701465.1	helix-turn-helix domain-containing protein	-
BB2000_RS15350	3451271..3451654	-	384	WP_020946512.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
BB2000_RS15355	3451651..3451872	-	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BB2000_RS15360	3452153..3453016	-	864	WP_041701468.1	YicC family protein	-
BB2000_RS15365	3453143..3453859	+	717	WP_004249760.1	ribonuclease PH	-
BB2000_RS15370	3453941..3454585	+	645	WP_004246493.1	orotate phosphoribosyltransferase	-
BB2000_RS15375	3454904..3455509	-	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
BB2000_RS15380	3455629..3456087	-	459	WP_004246490.1	dUTP diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (5-110)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14456.56 Da
• Isoelectric Point: 8.5125

>T29906 WP_020946512.1 NC_022000:c3451654-3451271 [Proteus mirabilis BB2000]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDLLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T29906 NC_022000:c3451654-3451271 [Proteus mirabilis BB2000]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCTGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT29906 WP_004246496.1 NC_022000:c3451872-3451651 [Proteus mirabilis BB2000]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT29906 NC_022000:c3451872-3451651 [Proteus mirabilis BB2000]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9