Detailed information of TA system TA029905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3131723..3132422
• Replicon: chromosome
• Accession: NC_022000
• Organism: Proteus mirabilis BB2000

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: BB2000_RS13925
• Protein ID: WP_004249093.1
• Coordinates: 3131723..3132109 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: BB2000_RS13930
• Protein ID: WP_004246828.1
• Coordinates: 3132102..3132422 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB2000_RS13910	3127742..3128323	-	582	WP_020946389.1	DNA-3-methyladenine glycosylase I	-
BB2000_RS13915	3128574..3129479	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
BB2000_RS13920	3129489..3131561	+	2073	WP_041701373.1	glycine--tRNA ligase subunit beta	-
BB2000_RS13925	3131723..3132109	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BB2000_RS13930	3132102..3132422	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
BB2000_RS13935	3132471..3132905	-	435	WP_020946391.1	hypothetical protein	-
BB2000_RS13940	3132898..3133782	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
BB2000_RS13945	3133997..3135283	-	1287	WP_020946392.1	DUF3748 domain-containing protein	-
BB2000_RS13950	3135420..3136037	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
BB2000_RS13955	3136339..3136962	+	624	WP_004246821.1	guanylate kinase	-
BB2000_RS13960	3137017..3137292	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T29905 WP_004249093.1 NC_022000:3131723-3132109 [Proteus mirabilis BB2000]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T29905 NC_022000:3131723-3132109 [Proteus mirabilis BB2000]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATTGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT29905 WP_004246828.1 NC_022000:3132102-3132422 [Proteus mirabilis BB2000]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT29905 NC_022000:3132102-3132422 [Proteus mirabilis BB2000]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97