Detailed information of TA system TA029904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 2669789..2670810
• Replicon: chromosome
• Accession: NC_022000
• Organism: Proteus mirabilis BB2000

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: BB2000_RS11955
• Protein ID: WP_020946192.1
• Coordinates: 2670241..2670810 (+)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: B4F2H3
• Locus tag: BB2000_RS11950
• Protein ID: WP_004245528.1
• Coordinates: 2669789..2670241 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB2000_RS11930	2665575..2666105	-	531	WP_004245524.1	RNA pyrophosphohydrolase	-
BB2000_RS11935	2666374..2667387	+	1014	WP_041701263.1	thiamine ABC transporter substrate binding subunit	-
BB2000_RS11940	2667387..2668967	+	1581	WP_020946191.1	thiamine/thiamine pyrophosphate ABC transporter permease ThiP	-
BB2000_RS11945	2668960..2669661	+	702	WP_004245527.1	thiamine ABC transporter ATP-binding protein ThiQ	-
BB2000_RS11950	2669789..2670241	+	453	WP_004245528.1	helix-turn-helix domain-containing protein	Antitoxin
BB2000_RS11955	2670241..2670810	+	570	WP_020946192.1	PIN domain-containing protein	Toxin
BB2000_RS11960	2670926..2673280	+	2355	WP_020946193.1	DNA polymerase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-113)

Antitoxin

• SinI-like, DNA-binding domain (80-125)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21574.06 Da
• Isoelectric Point: 7.3885

>T29904 WP_020946192.1 NC_022000:2670241-2670810 [Proteus mirabilis BB2000]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKHLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Nucleotide

• Length: 570 bp

>T29904 NC_022000:2670241-2670810 [Proteus mirabilis BB2000]
ATGACAAACTATACTGTTTTGCTTGATGCCTGTGTCATGTATCCAGCCCCTCTTAGAAGTTATTTAATGTATCTTGCTAA
TACTGGTTTATTTAGAGCACGTTGGAGTAATCAGATCCATGATGAATGGATCACTAATTTATTAGTCAACAATCCAACAT
TAACAGCTGAGCGACTAATACGAACCAGAGATTTAATGAATGCACATGTTCCTGATTGTTTAGTAGAAGGCTACGAACCG
CTTATTTGTGGTTTAAAGCTACCTGATCCTAATGATCGTCATGTGCTAGCAGCAGCAATAAAAGGACAGGCTCAAGCTAT
AATTACATTTAACTTAAAAGATTTTCCGCAAAAACACCTTAATTCTTTTGATATTTCAGCTATCCATCCTGATGAATTTT
TGAGTGACATGTTTGAATTAAATCCTAGTAGCTGTATTAAAGCGGCGCAACAACATAGACAAAGCCTAAAGAATCCACCA
ATGACCGTAGAGACCTTTTTAGGCTGTTTACAAAAGCAGAAATTACCCCAGTTTATTTCCCATTTACGGGCATTCCAGAT
ATTATTATAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16700.15 Da
• Isoelectric Point: 5.7723

>AT29904 WP_004245528.1 NC_022000:2669789-2670241 [Proteus mirabilis BB2000]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Nucleotide

• Length: 453 bp

>AT29904 NC_022000:2669789-2670241 [Proteus mirabilis BB2000]
ATGAATACGATAAGTGAGAGACTTAGTGCTGAAGATATTGCATTAGCAAAATTAAGTAGCCAAGAGCTATCCGCTGTTAT
GGATATTAATGGCAAAACGCAGAAGCTATCCATTATAGATAAGACGGGTAATAATCATATTGTACAAATACCAAATAGTG
CATTACGCCTAATGATTGAAATTCTTACTCAACTAGGGCAAGGGAATACTGTTAGTATCACACCAATCCATGCTGAGCTA
ACGACACAGGAAGCGGCTGATATACTCAATATGTCCCGTCCTACATTTGTAAAATTATTAGATACACGAGCGATACCCTA
CTCTAGAAAAGGAAATCGTAGGAAAGTTGCTTATGCTGATATTGTTGCTTATAAAAATGAATTGGAGCAAAAACGACTTG
ATGCCCTTGCTGAATTATCGCAATTAGATCAAGAAATGGATATGGGGTATTAA

Structures

Antitoxin

• AlphaFold DB: B4F2H3