Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 183280..183809 Replicon chromosome
Accession NC_021994
Organism Enterococcus faecium Aus0085

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag EFAU085_RS00905 Protein ID WP_002296560.1
Coordinates 183543..183809 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag EFAU085_RS00900 Protein ID WP_002296559.1
Coordinates 183280..183543 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFAU085_RS00890 (EFAU085_00183) 180654..182477 + 1824 WP_002294202.1 APC family permease -
EFAU085_RS00895 182619..182804 - 186 WP_002296558.1 transcriptional regulator -
EFAU085_RS00900 (EFAU085_00184) 183280..183543 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EFAU085_RS00905 (EFAU085_00185) 183543..183809 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
EFAU085_RS00910 (EFAU085_00186) 184010..184498 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
EFAU085_RS00915 (EFAU085_00188) 185039..185710 - 672 WP_002302663.1 ABC transporter permease -
EFAU085_RS00920 (EFAU085_00189) 185707..186624 - 918 WP_002302664.1 osmoprotectant ABC transporter substrate-binding protein -
EFAU085_RS00925 (EFAU085_00190) 186621..187262 - 642 WP_002293405.1 ABC transporter permease -
EFAU085_RS00930 (EFAU085_00191) 187266..188441 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T29901 WP_002296560.1 NC_021994:183543-183809 [Enterococcus faecium Aus0085]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T29901 NC_021994:183543-183809 [Enterococcus faecium Aus0085]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT29901 WP_002296559.1 NC_021994:183280-183543 [Enterococcus faecium Aus0085]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT29901 NC_021994:183280-183543 [Enterococcus faecium Aus0085]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References